Evaluation of the Most Common Viral Causes of Fever and Neutropenia in Children Hospitalized in Abuzar Children’s Medical Center in Ahvaz, Iran

IF 0.5 4区 医学 Q4 MICROBIOLOGY Jundishapur Journal of Microbiology Pub Date : 2023-06-16 DOI:10.5812/jjm-135198
A. Shamsizadeh, N. Neisi, Seyede Shabnam Seyedsalehi, M. Fathi, Mohsen Alisamir, Seyed Mohammadreza Mirkarimi
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Abstract

Background: Viral infections are the most common cause of fever and neutropenia in children without underlying disease, and data are still limited in this regard. Objective: This study aimed to identify the most common viral causes of fever and neutropenia in pediatrics. Methods: This descriptive-analytical study was conducted on pediatric patients younger than 18 years old referred to the pediatric emergency ward with fever as the chief complaint and no underlying diseases; patients with neutropenia and no evidence of bacterial infections in terms of different cultures were included in the study. After obtaining parental consent, nasopharyngeal swab specimens were taken from patients during the coronavirus disease 2019 (COVID-19) pandemic, and blood samples were analyzed to detect viruses in each patient. Results: Fifty patients (54.3%) had mild neutropenia (absolute neutrophil count (ANC): 1000 - 1500/μL), 40 patients (43.5%) had moderate neutropenia (ANC: 1000 - 500/μL), and 2 cases (2.2%) had severe neutropenia (ANC < 500/μL). Among all the cases, 19 cases were positive in terms of virus examination, including adenovirus (6.5%), enterovirus (5.4%), cytomegalovirus (CMV) (3.3%), Epstein-Barr virus (EBV) (3.3%), and Herpes virus 6 (2.2%). A significant correlation was found between enterovirus and neutropenia (P = 0.005). Conclusions: The most common viruses found in neutropenic children hospitalized due to fever without any underlying disease were adenovirus and enterovirus, respectively. Considering the good general condition and relatively quick recovery, consideration of viral causes is recommended in this category of patients, and it is better to avoid prescribing broad-spectrum antibiotics, and careful follow-up should be carried out.
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伊朗阿瓦兹阿布扎尔儿童医疗中心住院儿童发热和中性粒细胞减少症最常见病毒原因的评估
背景:病毒感染是没有潜在疾病的儿童发烧和中性粒细胞减少症的最常见原因,这方面的数据仍然有限。目的:本研究旨在确定儿科发热和中性粒细胞减少症最常见的病毒原因。方法:对转诊至儿科急诊病房的18岁以下以发热为主要主诉且无潜在疾病的儿童患者进行描述性分析研究;研究中包括了中性粒细胞减少症患者,并且在不同培养物中没有细菌感染的证据。在获得父母同意后,在2019冠状病毒病(新冠肺炎)大流行期间,从患者身上采集鼻咽拭子样本,并分析血液样本以检测每个患者的病毒。结果:50例(54.3%)患者出现轻度中性粒细胞减少症(中性粒细胞绝对计数(ANC):1000-1500/μL),40例(43.5%)患者出现中度中性粒细胞降低症(ANC:1000-500/μL,2例(2.2%)患者出现重度中性粒细胞减少症(ANC<500/μL)。在所有病例中,19例病毒检测呈阳性,包括腺病毒(6.5%)、肠道病毒(5.4%)、巨细胞病毒(CMV)(3.3%)、EB病毒(3.3%),和疱疹病毒6型(2.2%)。肠道病毒和中性粒细胞减少症之间存在显著相关性(P=0.005)。考虑到一般情况良好,恢复相对较快,建议这类患者考虑病毒原因,最好避免开广谱抗生素,并应仔细随访。
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来源期刊
CiteScore
1.30
自引率
0.00%
发文量
56
审稿时长
6-12 weeks
期刊介绍: Jundishapur Journal of Microbiology, (JJM) is the official scientific Monthly publication of Ahvaz Jundishapur University of Medical Sciences. JJM is dedicated to the publication of manuscripts on topics concerning all aspects of microbiology. The topics include medical, veterinary and environmental microbiology, molecular investigations and infectious diseases. Aspects of immunology and epidemiology of infectious diseases are also considered.
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