Bone Turnover Markers in Adults with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.

IF 2.3 4区医学 Q3 ENDOCRINOLOGY & METABOLISM International Journal of Endocrinology Pub Date : 2023-07-19 eCollection Date: 2023-01-01 DOI:10.1155/2023/9957194

Chao Li, Yali Cui, Wenjie Zhou, Yiduo Zhang, Xiaocui Huang, Fan Yu

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Abstract

Objective: Previous studies suggested that the level of bone turnover markers (BTMs) could be altered in patients with nonalcoholic fatty liver disease (NAFLD). We aim to provide a comprehensive understanding on the associations between BTMs and NAFLD in adults with a meta-analysis.

Methods: Articles published up to January 31, 2023, were systematically searched in PubMed, Web of Science, Cochrane database, Embase, and CNKI. The search formula is as follows: "nonalcoholic fatty liver disease" combined with the terms that bone turnover markers such as "osteocalcin," "collagen type I trimeric cross-linked peptide," and "procollagen type I N-terminal peptide." Stata 15.0 software was used to calculate the pooled OR (95% CI) and perform the heterogeneity test, sensitivity analysis, and publication bias.

Results: We identified 18 studies with a total of 12,310 participants. Statistical differences were found between patients with NAFLD compared to the control group for osteocalcin (n = 15 studies; SMD: -0.69; 95% CI: -0.73--0.64; P=0.002), procollagen type I N-terminal propeptide (n = 5 studies; SMD: -0.40; 95% CI: -0.80--0.00; P=0.049), and collagen type I cross-linked C-telopeptide (n = 7 studies; SMD: -0.16; 95% CI: -0.23--0.09); P < 0.001).

Conclusion: Bone turnover markers were lower in patients with NAFLD compared to the control group.

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成人非酒精性脂肪肝骨转换标志物的系统评价和荟萃分析

客观的先前的研究表明，非酒精性脂肪性肝病（NAFLD）患者的骨转换标志物（BTM）水平可能会改变。我们的目的是通过荟萃分析全面了解成人BTMs和NAFLD之间的关系。方法。截至2023年1月31日发表的文章在PubMed、Web of Science、Cochrane数据库、Embase和CNKI上进行了系统搜索。搜索公式如下：“非酒精性脂肪肝”与骨转换标志物（如“骨钙素”、“I型胶原三聚体交联肽”和“I型前胶原N-末端肽”）相结合。使用Stata 15.0软件计算合并OR（95%CI），并进行异质性测试、敏感性分析和发表偏倚。后果我们确定了18项研究，共有12310名参与者。与对照组相比，NAFLD患者的骨钙素（n = 15项研究；SMD:−0.69；95%置信区间：−0.73–−0.64；P=0.002）、I型前胶原N-末端前肽（N = 5项研究；SMD:-0.40；95%CI：−0.80−0.00；P=0.049）和I型胶原交联的C-末端肽（n = 7项研究；SMD:−0.16；95%置信区间：−0.23-−0.09）；P＜0.001）。结论与对照组相比，NAFLD患者的骨转换标志物较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Endocrinology ENDOCRINOLOGY & METABOLISM-

CiteScore

5.20

自引率

0.00%

发文量

147

审稿时长

1 months

期刊介绍： International Journal of Endocrinology is a peer-reviewed, Open Access journal that provides a forum for scientists and clinicians working in basic and translational research. The journal publishes original research articles, review articles, and clinical studies that provide insights into the endocrine system and its associated diseases at a genomic, molecular, biochemical and cellular level.