Mutation Of Amino Acids In Sars-Cov-2 May Be Responsible For Cov-2 Vaccine Long Term Inefficiency

Abstract

SARS-Cov-2 vaccines confer protection for about two months, hence the need for booster dose. Inefficiency of the vaccines may be attributed to mutated amino acids leading to change in structure and function of immunogenetic viral particles. Therefore literature search was carried out with a view to identifying problems of CoV-2 vaccine long term inefficiency, using missensed amino acids of the immunogens. Narrative review of six different COVID-19 vaccines administered at different centres to a total population of 98,979 individuals aged ≥18-95 years was adopted. Number of individuals that came down with infection post vaccination, vaccine dose administered, recorded mortality, post vaccinated infection-free individuals, immunogenicity status, missense mutation, incidence, probability and quality of mutation among amino acids sequences of the vaccinated viral particles were determined. Findings have shown that some live-attenuted vaccines such as BBIBP-CorV, WBIP, ChAdOxnCoV and Ad26.CoV2.5 are efficacious, but could induce mortal infection and mutation of amino acids such as aspartic acid, glycine, cysteine, aspartate, tyrosine, phenylalanine, threonine, serine, alanine, methionine, leucine and lysine. Mutation of some specific amino acids could be responsible for severe pathogenicity of SARS-CoV-2 and vaccine failure. Modalities that regulate synthesis of nucleobases and amino acids could be used to avert vaccine failure and improves immunogenicity of the vaccines.