A prospective decision-impact study incorporating Breast Cancer Index into extended endocrine therapy decision-making

IF 0.4 Q4 ONCOLOGY Breast Cancer Management Pub Date : 2019-03-01 DOI:10.2217/BMT-2019-0001

T. Sanft, A. Berkowitz, B. Schroeder, C. Hatzis, C. Schnabel, A. Brufsky, G. Gustavsen, L. Pusztai, G. J. Londen

引用次数: 9

Abstract

Aim: To prospectively assess the impact of gene expression-based assay Breast Cancer Index (BCI) on extended endocrine therapy (EET) decision-making. Patients & methods: The BCI-tested samples from primary tumors (Stage I–III, hormone receptor positive breast cancer, >3.5 year endocrine therapy). Patients and physicians completed questionnaires on EET preferences and decision conflict. Using these data, a fact-based economic model was developed to project the cost impact of BCI. Results: The BCI results affected treatment recommendations for 42/141 patients (overall mean, 62 year; 83% postmenopausal; 63% Stage I). Patient decision conflict decreased pre- to post-test. The BCI-related projected net savings (US$5190/patient) was robust under sensitivity analysis. Conclusion: Incorporating BCI into clinical practice meaningfully impacted physician EET recommendations and decreased patient decision conflict, with projected cost savings.

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将癌症指数纳入扩展内分泌治疗决策的前瞻性决策影响研究

目的：前瞻性评估基于基因表达测定的癌症乳腺癌指数（BCI）对扩展内分泌治疗（EET）决策的影响。患者和方法：来自原发性肿瘤（I–III期，激素受体阳性乳腺癌症，>3.5年内分泌治疗）的BCI测试样本。患者和医生完成了关于EET偏好和决策冲突的问卷调查。利用这些数据，开发了一个基于事实的经济模型来预测脑机接口的成本影响。结果：脑机接口结果影响了42/141名患者的治疗建议（总体平均值，62岁；83%绝经后；63%为I期）。试验前后患者决策冲突减少。根据敏感性分析，脑机接口相关的预计净节省（5190美元/名患者）是稳健的。结论：将脑机接口纳入临床实践有意义地影响了医生的EET建议，减少了患者的决策冲突，并预计节省了成本。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast Cancer Management ONCOLOGY-

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Breast Cancer Management (ISSN: 1758-1923) addresses key issues in disease management by exploring the best patient-centered clinical research and presenting this information both directly, as clinical findings, and in practice-oriented formats of direct relevance in the clinic. The journal also highlights significant advances in basic and translational research, and places them in context for future therapy. Breast Cancer Management provides oncologists and other health professionals with the latest findings and opinions on reducing the burden of this widespread disease. Recent research findings and advances clinical practice in the field are reported and analyzed by international experts. The journal presents this information in clear, accessible formats. All articles are subject to independent review by a minimum of three independent experts. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal’s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3. Coverage includes: Diagnosis and imaging, Surgical approaches, Radiotherapy, Systemic therapies, Cancer clinical trials, Genetic aspects of disease, Personalized medicine, Translational research and biomarker studies, Management of psychological distress, Epidemiological studies, Pharmacoeconomics, Evidence-based treatment guidelines.