Hydrogel-Crosslinked Microneedles Based on Microwave-Assisted Drying Method

Abstract

We present a method and several applications for the synthesis of hydrogel-crosslinked microneedle arrays utilizing microwave-assisted drying, ensuring a significant reduction in reaction preparation time while maintaining quality. We demonstrate the feasibility of drying hydrogels using microwaves and thus extend to crosslinked microneedle fabrication. Crosslinking was performed using 1,4-butanediol diglycidyl ether (BDDE) as a crosslinking agent. Infrared spectra of the microneedle arrays were measured with attenuated total reflection-Fourier transform infrared (ATR-FTIR). The surface morphology of the microneedle arrays was observed with scanning electron microscopy (SEM). The microneedle arrays were evaluated in terms of mechanical strength, swelling kinetics, rheological properties, degradation rate, and glucose iontophoresis. The results show that this method can shorten the reaction preparation time by 5 hours, and the prepared crosslinked microneedle array has better crosslinking efficiency, swelling effect, and greater mechanical strength than traditional methods.