Formulation and Evaluation of Punica granatum L Seed Oil-loaded Cosmetic Cream: Its In-vitro Antioxidant Activity

Abstract

Cosmetic creams for the antioxidant activity of Punica granutum L seed oil (PSO) were formulated in different concentrations of oil in F1 to F6 formulations of cosmetic creams and their physicochemical properties were evaluated. There are several different pharmacological actions attributed to P. granutum L seed oil. The prepared cream was evaluated its properties like pH, resistance to flow, spreadability size, and surface charge value, and ex-vivo release study were performed. All results are found within the limit and it complies with the specification as per requirements. Good in-vitro DPPH scavenging activity was observed from the optimized batches throughout the preparation. To determine the stability profile, cosmetic creams containing PSO (Batches F1 through F6) were exposed to a three-month accelerated stability study in accordance with ICH recommendations. From this study it was concluded that prepared batches used for various treatments of skin disorders.