Effect of new oral anticoagulants on microcirculation in ischemic diabetic foot ulcer

K. Attia, M. Moawad, Walied Khereba
{"title":"Effect of new oral anticoagulants on microcirculation in ischemic diabetic foot ulcer","authors":"K. Attia, M. Moawad, Walied Khereba","doi":"10.4103/azmj.azmj_60_21","DOIUrl":null,"url":null,"abstract":"Background and aim Diabetic patients with foot ulcer and peripheral ischemia were shown to be associated with hypercoagulation and dysfunction in the fibrinolytic system that in turn would affect the healing of the ulcer. The authors aimed to investigate the role of rivaroxaban in improving the microcirculation of the skin and peripheral tissues and how it can improve ischemic diabetic foot ulcers. Patient and methods The authors conducted an observational retrospective case–control study at Al-Azhar University Hospital, New Damietta, from January 2015 till December 2020. Diabetic patients with foot ulcer and peripheral limb ischemia who received rivaroxaban till ulcer healing were considered as the case group, whereas patients who did not receive rivaroxaban were considered as the control group. Clinical assessment and pulse oximeter were used for the assessment of transcutaneous microcirculation. Results Throughout the 5 years of the study, 172 patients were included; the case group included 87 patients and the control group included 85 patients. There was a significant difference between the two groups regarding the improvement of limb ischemia, tissue plasminogen activator antigen, and transcutaneous microcirculation (P<0.05). Before the treatment, there was a significant correlation between both permeability coefficient and plasma fibrinogen and transcutaneous microcirculation. Conclusion The oxygenation of the ulcer and the microcirculation were found to be improved in the case group and accelerate wound healing in the ischemic diabetic foot.","PeriodicalId":7711,"journal":{"name":"Al-Azhar Assiut Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Al-Azhar Assiut Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/azmj.azmj_60_21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background and aim Diabetic patients with foot ulcer and peripheral ischemia were shown to be associated with hypercoagulation and dysfunction in the fibrinolytic system that in turn would affect the healing of the ulcer. The authors aimed to investigate the role of rivaroxaban in improving the microcirculation of the skin and peripheral tissues and how it can improve ischemic diabetic foot ulcers. Patient and methods The authors conducted an observational retrospective case–control study at Al-Azhar University Hospital, New Damietta, from January 2015 till December 2020. Diabetic patients with foot ulcer and peripheral limb ischemia who received rivaroxaban till ulcer healing were considered as the case group, whereas patients who did not receive rivaroxaban were considered as the control group. Clinical assessment and pulse oximeter were used for the assessment of transcutaneous microcirculation. Results Throughout the 5 years of the study, 172 patients were included; the case group included 87 patients and the control group included 85 patients. There was a significant difference between the two groups regarding the improvement of limb ischemia, tissue plasminogen activator antigen, and transcutaneous microcirculation (P<0.05). Before the treatment, there was a significant correlation between both permeability coefficient and plasma fibrinogen and transcutaneous microcirculation. Conclusion The oxygenation of the ulcer and the microcirculation were found to be improved in the case group and accelerate wound healing in the ischemic diabetic foot.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
新型口服抗凝剂对缺血性糖尿病足溃疡微循环的影响
背景和目的糖尿病足溃疡和外周缺血患者与高凝状态和纤溶系统功能障碍有关,这反过来又会影响溃疡的愈合。作者旨在研究利伐沙班在改善皮肤和外周组织微循环方面的作用,以及它如何改善缺血性糖尿病足溃疡。患者和方法作者于2015年1月至2020年12月在新达米埃塔爱资哈尔大学医院进行了一项观察性回顾性病例对照研究。将接受利伐沙班治疗至溃疡愈合的足部溃疡和外周肢体缺血的糖尿病患者视为病例组,而未接受利伐沙班治疗的患者视为对照组。临床评估和脉搏血氧计用于评估经皮微循环。结果在整个5年的研究中,172名患者被纳入;病例组87例,对照组85例。两组在改善肢体缺血、组织纤溶酶原激活物抗原和经皮微循环方面有显著差异(P<0.05),治疗前渗透系数与血浆纤维蛋白原和经皮微循环均呈显著相关。结论病例组可改善糖尿病足缺血性溃疡的氧合及微循环,促进创面愈合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
11
审稿时长
34 weeks
期刊最新文献
Conservative management versus ventilation tube insertion in children with otitis media with effusion accompanying cleft palate A study of the effect of some musical compositions on glucagon-like peptide 1, insulin, leptin, and body weight of crowded adult albino rats Protective role of Coenzyme Q10 on ultrastructure effect of sodium fluoride on the liver of adult male albino rats Comparative study between manipulation under anesthesia combined with local steroid injection versus local steroid injection alone in resistant cases of coccydynia Oral versus intravenous omeprazole in management of bleeding peptic ulcer: a randomized controlled trial
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1