{"title":"Investigations of Electrogenic Ion Transport by Na+,K+-ATPase in Bilayer Lipid Membranes by Impedance Method","authors":"V. S. Sokolov","doi":"10.1134/S1990747822050117","DOIUrl":null,"url":null,"abstract":"<p>The results of investigation of electrogenic transport by the Na<sup>+</sup>,K<sup>+</sup>-ATPase, the enzyme providing the active transport of Na<sup>+</sup> and K<sup>+</sup> ions through cell membrane, are reviewed. The main contribution to electric current generated through the functioning of the Na<sup>+</sup>,K<sup>+</sup>-ATPase is assigned to the movements of ions in access channels—the channel-like structures connecting the ion binding sites with the solutions. The electrogenic transport was studied in a model system consisting of a bilayer lipid membrane with adsorbed membrane fragments containing the Na<sup>+</sup>,K<sup>+</sup>-ATPase. The impedance method applied to this study allowed the investigation of access channels in the Na<sup>+</sup>,K<sup>+</sup>-ATPase. The review notes a significant contribution of Yu.A. Chizmadzhev to the development of the theoretical model of transport processes in the Na<sup>+</sup>,K<sup>+</sup>-ATPase.</p>","PeriodicalId":484,"journal":{"name":"Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology","volume":"16 4","pages":"282 - 290"},"PeriodicalIF":1.1000,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology","FirstCategoryId":"2","ListUrlMain":"https://link.springer.com/article/10.1134/S1990747822050117","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The results of investigation of electrogenic transport by the Na+,K+-ATPase, the enzyme providing the active transport of Na+ and K+ ions through cell membrane, are reviewed. The main contribution to electric current generated through the functioning of the Na+,K+-ATPase is assigned to the movements of ions in access channels—the channel-like structures connecting the ion binding sites with the solutions. The electrogenic transport was studied in a model system consisting of a bilayer lipid membrane with adsorbed membrane fragments containing the Na+,K+-ATPase. The impedance method applied to this study allowed the investigation of access channels in the Na+,K+-ATPase. The review notes a significant contribution of Yu.A. Chizmadzhev to the development of the theoretical model of transport processes in the Na+,K+-ATPase.
期刊介绍：
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology is an international peer reviewed journal that publishes original articles on physical, chemical, and molecular mechanisms that underlie basic properties of biological membranes and mediate membrane-related cellular functions. The primary topics of the journal are membrane structure, mechanisms of membrane transport, bioenergetics and photobiology, intracellular signaling as well as membrane aspects of cell biology, immunology, and medicine. The journal is multidisciplinary and gives preference to those articles that employ a variety of experimental approaches, basically in biophysics but also in biochemistry, cytology, and molecular biology. The journal publishes articles that strive for unveiling membrane and cellular functions through innovative theoretical models and computer simulations.
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