The mechanism and diagnostic Value of Tbx20 in cardiovascular diseases

IF 0.9 Q4 GENETICS & HEREDITY Gene Reports Pub Date : 2023-03-01 DOI:10.1016/j.genrep.2022.101723

Xue Gao , Bo Yan

引用次数: 1

Abstract

Cardiovascular disease is a common disease that threatens human health. It is very important to discover the underlying pathogenesis. Tbx20, a member of the TBX1 subfamily, possesses highly conserved DNA binding domains, transcriptional activation domains, and transcriptional suppression domains. The expression of Tbx20 within the heart is spatially and temporally specific. Meanwhile, it also regulates other genes involved in heart development to regulate cardiac morphogenesis. Thus, Tbx20 plays an important role in regulating the shape and function of the heart. Abnormal Tbx20 function may cause heart dysfunction and abnormal morphology. The Tbx20 has been linked to a variety of heart diseases, including atrial septal defect (ASD), ventricular septal defect (VSD), tetralogy of Fallot (TOF), dilated cardiomyopathy (DCM), and so on. Tbx20 also plays a major part in promoting cardiomyocyte proliferation and regeneration. This article reviews the expression of Tbx20 in the heart and its variation detected in heart disease. The role of Tbx20 in regeneration of myocardial was also touched upon.

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Tbx20在心血管疾病中的作用机制及诊断价值

心血管疾病是威胁人类健康的常见病。发现潜在的发病机制是非常重要的。Tbx20是TBX1亚家族的一员，具有高度保守的DNA结合域、转录激活域和转录抑制域。Tbx20在心脏内的表达具有空间和时间特异性。同时，它还调节心脏发育过程中涉及的其他基因来调节心脏的形态发生。因此，Tbx20在调节心脏形状和功能方面起着重要作用。Tbx20功能异常可引起心功能异常和形态异常。Tbx20与多种心脏疾病有关，包括房间隔缺损(ASD)、室间隔缺损(VSD)、法洛四联症(TOF)、扩张型心肌病(DCM)等。Tbx20在促进心肌细胞增殖和再生中也起着重要作用。本文综述了Tbx20在心脏中的表达及其在心脏病中检测到的变异。并探讨了Tbx20在心肌再生中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gene Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

7.70%

发文量

246

审稿时长

49 days

期刊介绍： Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.