Carcinoma Breast: Correlation of Immunohistohemical Expression of Cyclin D1 and Its Correlation with Clinicopathological Parameters in Indian Patients at Tertiary Care Hospital

Abstract

Aim: To study the prevalence of Cyclin D1 expression and its correlation with other clinicopathological parameters like age, tumor size, lymph node status, MBR grade, and expression of other immunohistochemical markers like ER, PR, Her 2 - neu, and Ki67. Material and Methods: Thirty cases diagnosed were included in the study. All the cases were subjected to routine histopathology along with IHC for ER PR, Her2-neu, Ki67, and Cyclin D1. Results: CylinD1 positivity was found in 70% of cases. Our study presented the following distribution of cases Luminal A, N = 6(20%), Luminal B, N = 5(16.7%), Triple-negative, N = 10(33.3%), Normal Like = 7(23.3%), Her2/neu enriched = 2(6.7%). N = 4(40%) of triple-negative molecular subtype were positive for the cyclin D1. Cyclin D1 positivity showed a strong correlation with ER, PR, Her2-neu, and Ki67 status. However, no other significant correlation was found with other factors. Conclusion: This study shows a positive correlation of CyclinD1 with many other prognostic markers like molecular subtype, ER, PR, Her2/neu, and Ki67. With the advent of CD4/6 inhibitors and their potential therapeutic effects in breast carcinoma, Cyclin D1 becomes a potential prognostic IHC marker and can aid in patient management in cases of breast carcinoma. Its association with other established markers and clinicopathological parameters needs to be researched thoroughly.