Enhanced brain network flexibility by physical exercise in female methamphetamine users.

Abstract

Methamphetamine (MA) abuse is increasing worldwide, and evidence indicates that MA causes degraded cognitive functions such as executive function, attention, and flexibility. Recent studies have shown that regular physical exercise can ameliorate the disturbed functions. However, the potential functional network alterations resulting from physical exercise have not been extensively studied in female MA users. We collaborated with a drug rehabilitation center for this study to investigate changes in brain activity and network dynamics after two types of acute and long-term exercise interventions based on 64-channel electroencephalogram recordings of seventy-nine female MA users, who were randomly divided into three groups: control group (CG), dancing group (DG) and bicycling group (BG). Over a 12-week period, we observed a clear drop in the rate of brain activity in the exercise groups, especially in the frontal and temporal regions in the DG and the frontal and occipital regions in the BG, indicating that exercise might suppress hyperactivity and that different exercise types have distinct impacts on brain networks. Importantly, both exercise groups demonstrated enhancements in brain flexibility and network connectivity entropy, particularly after the acute intervention. Besides, a significantly negative correlation was found between Δattentional bias and Δbrain flexibility after acute intervention in both DG and BG. Analysis strongly suggested that exercise programs can reshape patient brains into a highly energy-efficient state with a lower activity rate but higher information communication capacity and more plasticity for potential cognitive functions. These results may shed light on the potential therapeutic effects of exercise interventions for MA users.

Supplementary information: The online version contains supplementary material available at 10.1007/s11571-022-09848-5.