Current understandings and perspectives of petroleum hydrocarbons in Alzheimer’s disease and Parkinson’s disease: a global concern

IF 5.8 3区环境科学与生态学 N/A ENVIRONMENTAL SCIENCES Environmental Science and Pollution Research Pub Date : 2022-01-09 DOI:10.1007/s11356-021-17931-3

Rajalakshmi Rajendran, Roshni Pushpa Ragavan, Abdullah G. Al-Sehemi, Md. Sahab Uddin, Lotfi Aleya, Bijo Mathew

{"title":"Current understandings and perspectives of petroleum hydrocarbons in Alzheimer’s disease and Parkinson’s disease: a global concern","authors":"Rajalakshmi Rajendran, Roshni Pushpa Ragavan, Abdullah G. Al-Sehemi, Md. Sahab Uddin, Lotfi Aleya, Bijo Mathew","doi":"10.1007/s11356-021-17931-3","DOIUrl":null,"url":null,"abstract":"<div><h2>Abstract\n</h2><div><p>Over the last few decades, the global prevalence of neurodevelopmental and neurodegenerative illnesses has risen rapidly. Although the aetiology remains unclear, evidence is mounting that exposure to persistent hydrocarbon pollutants is a substantial risk factor, predisposing a person to neurological diseases later in life. Epidemiological studies correlate environmental hydrocarbon exposure to brain disorders including neuropathies, cognitive, motor and sensory impairments; neurodevelopmental disorders like autism spectrum disorder (ASD); and neurodegenerative disorders like Alzheimer’s disease (AD) and Parkinson’s disease (PD). Particulate matter, benzene, toluene, ethylbenzene, xylenes, polycyclic aromatic hydrocarbons and endocrine-disrupting chemicals have all been linked to neurodevelopmental problems in all class of people. There is mounting evidence that supports the prevalence of petroleum hydrocarbon becoming neurotoxic and being involved in the pathogenesis of AD and PD. More study is needed to fully comprehend the scope of these problems in the context of unconventional oil and natural gas. This review summarises in vitro, animal and epidemiological research on the genesis of neurodegenerative disorders, highlighting evidence that supports inexorable role of hazardous hydrocarbon exposure in the pathophysiology of AD and PD. In this review, we offer a summary of the existing evidence gathered through a Medline literature search of systematic reviews and meta-analyses of the most important epidemiological studies published so far.</p></div></div>","PeriodicalId":545,"journal":{"name":"Environmental Science and Pollution Research","volume":null,"pages":null},"PeriodicalIF":5.8000,"publicationDate":"2022-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Science and Pollution Research","FirstCategoryId":"93","ListUrlMain":"https://link.springer.com/article/10.1007/s11356-021-17931-3","RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"N/A","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}

引用次数: 3

Abstract

Over the last few decades, the global prevalence of neurodevelopmental and neurodegenerative illnesses has risen rapidly. Although the aetiology remains unclear, evidence is mounting that exposure to persistent hydrocarbon pollutants is a substantial risk factor, predisposing a person to neurological diseases later in life. Epidemiological studies correlate environmental hydrocarbon exposure to brain disorders including neuropathies, cognitive, motor and sensory impairments; neurodevelopmental disorders like autism spectrum disorder (ASD); and neurodegenerative disorders like Alzheimer’s disease (AD) and Parkinson’s disease (PD). Particulate matter, benzene, toluene, ethylbenzene, xylenes, polycyclic aromatic hydrocarbons and endocrine-disrupting chemicals have all been linked to neurodevelopmental problems in all class of people. There is mounting evidence that supports the prevalence of petroleum hydrocarbon becoming neurotoxic and being involved in the pathogenesis of AD and PD. More study is needed to fully comprehend the scope of these problems in the context of unconventional oil and natural gas. This review summarises in vitro, animal and epidemiological research on the genesis of neurodegenerative disorders, highlighting evidence that supports inexorable role of hazardous hydrocarbon exposure in the pathophysiology of AD and PD. In this review, we offer a summary of the existing evidence gathered through a Medline literature search of systematic reviews and meta-analyses of the most important epidemiological studies published so far.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

石油碳氢化合物在阿尔茨海默病和帕金森病中的当前理解和观点:一个全球关注的问题

摘要在过去的几十年里，神经发育和神经退行性疾病的全球患病率迅速上升。尽管病因尚不清楚，但越来越多的证据表明，暴露于持久性碳氢化合物污染物是一个重要的风险因素，使人在以后的生活中容易患上神经系统疾病。流行病学研究将环境碳氢化合物暴露与脑部疾病(包括神经病、认知、运动和感觉障碍)联系起来;自闭症谱系障碍(ASD)等神经发育障碍;以及神经退行性疾病，如阿尔茨海默病(AD)和帕金森病(PD)。颗粒物、苯、甲苯、乙苯、二甲苯、多环芳烃和干扰内分泌的化学物质都与各类人群的神经发育问题有关。越来越多的证据支持石油烃具有神经毒性，并参与AD和PD的发病机制。在非常规石油和天然气的背景下，需要进行更多的研究来全面了解这些问题的范围。本文综述了神经退行性疾病发生的体外、动物和流行病学研究，强调了危险碳氢化合物暴露在AD和PD病理生理中的不可避免的作用。在这篇综述中，我们通过Medline文献检索，对迄今为止发表的最重要的流行病学研究进行系统综述和荟萃分析，总结了现有证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Environmental Science and Pollution Research 环境科学-环境科学

CiteScore

8.70

自引率

17.20%

发文量

6549

审稿时长

3.8 months

期刊介绍： Environmental Science and Pollution Research (ESPR) serves the international community in all areas of Environmental Science and related subjects with emphasis on chemical compounds. This includes: - Terrestrial Biology and Ecology - Aquatic Biology and Ecology - Atmospheric Chemistry - Environmental Microbiology/Biobased Energy Sources - Phytoremediation and Ecosystem Restoration - Environmental Analyses and Monitoring - Assessment of Risks and Interactions of Pollutants in the Environment - Conservation Biology and Sustainable Agriculture - Impact of Chemicals/Pollutants on Human and Animal Health It reports from a broad interdisciplinary outlook.