Correlation of microembolism risk factors with age in the ischemic stroke recovery period

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Bulletin of Russian State Medical University Pub Date : 2022-12-12 DOI:10.24075/brsmu.2022.058

E. Orlova, A. Berdalin, V. Lelyuk

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Abstract

Identification of the age-related features of interaction between the risk factors of microembolism can improve understanding of the mechanisms underlying the development of ischemic stroke (IS). The study was aimed to assess the effects of age and other risk factors of stroke on the biophysical characteristics of microembolic signals (MES) recorded during the ischemic stroke recovery period. Transcranial Doppler ultrasound (TCD) involving microembolus detection (MED) was performed in 515 people, the data of 28 patients having a history of ischemic stroke, among them 9 women (32%) and 19 men (68%) aged 33–78 (average age 58 ± 13 years), were included in the study. Using the mixed-effects linear model it was found that age and interaction between age and atrial fibrillation affected the power of MES. The increase in the power of the recorded MES with age is observed, that is especially evident in patients with atrial fibrillation (р < 0.0005). As for cardioembolic IS variant, the power and duration of MES turn out to be significantly higher in elderly patients (p < 0.0005). The power of MES gradually increases with age in patients with no atherosclerosis and gradually decreases in patients with atherosclerosis, while MES power in patients with atherosclerosis in general (all age groups) is significantly higher (р < 0.0005) than that observed in patients with no atherosclerosis.

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缺血性脑卒中恢复期微栓塞危险因素与年龄的关系

识别微栓塞风险因素之间相互作用的年龄相关特征可以提高对缺血性卒中（IS）发生机制的理解。该研究旨在评估年龄和其他中风风险因素对缺血性中风恢复期记录的微栓子信号（MES）的生物物理特征的影响。对515人进行了涉及微栓子检测（MED）的经颅多普勒超声（TCD），研究中包括28名有缺血性卒中史的患者的数据，其中9名女性（32%）和19名男性（68%），年龄为33-78岁（平均年龄58±13岁）。使用混合效应线性模型，发现年龄和年龄与心房颤动之间的相互作用影响MES的功率。观察到记录的MES的功率随着年龄的增长而增加，这在心房颤动患者中尤其明显（р<0.0005）。至于心脏栓塞is变体，MES的功率和持续时间在老年患者中显著较高（p＜0.0005）。无动脉粥样硬化患者MES的功率随着年龄的增长而逐渐增加，而动脉粥样硬化患者（所有年龄组）的MES能力明显高于无动脉粥样硬化患者（р<0.0005）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Russian State Medical University MEDICINE, GENERAL & INTERNAL-

CiteScore

0.80

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0.00%

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期刊介绍： Bulletin of Russian State Medical University (Bulletin of RSMU, ISSN Print 2500–1094, ISSN Online 2542–1204) is a peer-reviewed medical journal of Pirogov Russian National Research Medical University (Moscow, Russia). The original language of the journal is Russian (Vestnik Rossiyskogo Gosudarstvennogo Meditsinskogo Universiteta, Vestnik RGMU, ISSN Print 2070–7320, ISSN Online 2070–7339). Founded in 1994, it is issued once every two months publishing articles on clinical medicine and medical and biological sciences, first of all oncology, neurobiology, allergy and immunology, medical genetics, medical microbiology and infectious diseases. Every issue is thematic. Deadlines for manuscript submission are announced in advance. The number of publications on topics in spite of the issue topic is limited. The journal accepts only original articles submitted by their authors, including articles that present methods and techniques, clinical cases and opinions. Authors must guarantee that their work has not been previously published elsewhere in whole or in part and in other languages and is not under consideration by another scientific journal. The journal publishes only one review per issue; the review is ordered by the editors.