Assessment of Inflammatory Biomarkers, Total IgE levels, SNOT-22 scores in Allergic Rhinitis patients

IF 0.2 Q4 OTORHINOLARYNGOLOGY ENT Updates Pub Date : 2019-08-01 DOI:10.32448/ENTUPDATES.581445
D. Yazici
{"title":"Assessment of Inflammatory Biomarkers, Total IgE levels, SNOT-22 scores in Allergic Rhinitis patients","authors":"D. Yazici","doi":"10.32448/ENTUPDATES.581445","DOIUrl":null,"url":null,"abstract":"Objectives: The aim of this study is to assess neutrophil-lymphocyte ratio (NLR), mean platelet volume (MPV), platelet-lymphocyte ratio (PLR) and eosinophil-lymphocyte ratio (ELR) of allergic rhinitis patients and compare our findings with healthy controls. We also analyzed the effect of severity of allergic rhinitis on hematological parameters and total IgE levels of the patients. Methods: A total of forty-six patients diagnosed having allergic rhinitis according to Allergic Rhinitis and its Impact on Asthma (ARIA) criteria and forty-six healthy, age and sex-matched subjects were included in this study. The clinical records of the patients were retrospectively analyzed and age, gender, skin prick test results, complete blood counts, total IgE levels and Sino-Nasal Outcome Test (SNOT) 22 scores were recorded for assessment of neutrophil-lymphocyte ratio (NLR), mean platelet volume (MPV), platelet-lymphocyte ratio (PLR) and eosinophil-lymphocyte ratio (ELR) of the patients. Results: Eosinophil count, eosinophil percentage and ELR value of the study group were significantly higher than the control group. (p=0,001, p=0,001, p=0,001 respectively) The cut-off value for ELR was ≥0,105. (sensitivity=0,61, specificity=0,76, AUC=0,703) Total IgE levels of patients with positive skin prick test were significantly higher than patients with negative skin prick test. (p=0,019) The cut-off value for total IgE was ≥63 IU/mL. (sensitivity=0,59, specificity=0,74, AUC=0,706). Conclusion: ELR is a valuable marker for predicting allergic rhinitis. However, it does not correlate with the severity of the disease. Total IgE levels increase in patients with positive skin prick tests. Also, total IgE level does not correlate with the severity of allergic rhinitis.","PeriodicalId":41744,"journal":{"name":"ENT Updates","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ENT Updates","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32448/ENTUPDATES.581445","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Objectives: The aim of this study is to assess neutrophil-lymphocyte ratio (NLR), mean platelet volume (MPV), platelet-lymphocyte ratio (PLR) and eosinophil-lymphocyte ratio (ELR) of allergic rhinitis patients and compare our findings with healthy controls. We also analyzed the effect of severity of allergic rhinitis on hematological parameters and total IgE levels of the patients. Methods: A total of forty-six patients diagnosed having allergic rhinitis according to Allergic Rhinitis and its Impact on Asthma (ARIA) criteria and forty-six healthy, age and sex-matched subjects were included in this study. The clinical records of the patients were retrospectively analyzed and age, gender, skin prick test results, complete blood counts, total IgE levels and Sino-Nasal Outcome Test (SNOT) 22 scores were recorded for assessment of neutrophil-lymphocyte ratio (NLR), mean platelet volume (MPV), platelet-lymphocyte ratio (PLR) and eosinophil-lymphocyte ratio (ELR) of the patients. Results: Eosinophil count, eosinophil percentage and ELR value of the study group were significantly higher than the control group. (p=0,001, p=0,001, p=0,001 respectively) The cut-off value for ELR was ≥0,105. (sensitivity=0,61, specificity=0,76, AUC=0,703) Total IgE levels of patients with positive skin prick test were significantly higher than patients with negative skin prick test. (p=0,019) The cut-off value for total IgE was ≥63 IU/mL. (sensitivity=0,59, specificity=0,74, AUC=0,706). Conclusion: ELR is a valuable marker for predicting allergic rhinitis. However, it does not correlate with the severity of the disease. Total IgE levels increase in patients with positive skin prick tests. Also, total IgE level does not correlate with the severity of allergic rhinitis.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
变应性鼻炎患者炎症生物标志物、总IgE水平、SNOT-22评分的评估
目的:评价变应性鼻炎患者的中性粒细胞-淋巴细胞比率(NLR)、平均血小板体积(MPV)、血小板-淋巴细胞比率(PLR)和嗜酸性粒细胞-淋巴细胞比率(ELR),并与健康对照进行比较。我们还分析了变应性鼻炎严重程度对患者血液学参数和总IgE水平的影响。方法:根据变态反应性鼻炎及其对哮喘的影响(ARIA)标准诊断为变态反应性鼻炎的患者46例,年龄和性别匹配的健康受试者46例。回顾性分析患者的临床资料,记录患者的年龄、性别、皮肤点刺试验结果、全血计数、总IgE水平和鼻鼻预后试验(SNOT) 22评分,评估患者的中性粒细胞-淋巴细胞比(NLR)、平均血小板体积(MPV)、血小板-淋巴细胞比(PLR)和嗜酸性粒细胞-淋巴细胞比(ELR)。结果:研究组嗜酸性粒细胞计数、嗜酸性粒细胞百分比及ELR值均显著高于对照组。(p=0,001, p=0,001, p=0,001) ELR的临界值≥0,105。(敏感性=0,61,特异性=0,76,AUC=0,703)皮刺试验阳性患者总IgE水平显著高于皮刺试验阴性患者。(p= 0.019)总IgE临界值≥63 IU/mL。(灵敏度=0,59,特异性=0,74,AUC=0,706)。结论:ELR是预测变应性鼻炎的重要指标。然而,它与疾病的严重程度无关。皮肤点刺试验阳性患者总IgE水平升高。此外,总IgE水平与变应性鼻炎的严重程度无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
ENT Updates
ENT Updates OTORHINOLARYNGOLOGY-
自引率
0.00%
发文量
0
审稿时长
14 weeks
期刊最新文献
Frankie Valli: How Stapes Surgery Saved His Career Domenico Cotugno (1736-1822), Antonio Scarpa (1752-1832), and Alfonso Corti (1822-1876): The Most Important Discoveries of the Inner Ear Made by Young Italian Physicians—Domenico Cotugno Association of Face Mask Use With Nasal Symptoms And Mucociliary Clearance Examination of the Clinic, Radiologic, and Demographic Characteristics of 436 Patients with Nasal Fracture Ear Nose Throat Foreign Bodies in Children: Impact of the COVID-19 Pandemic
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1