Assessment of Inflammatory Biomarkers, Total IgE levels, SNOT-22 scores in Allergic Rhinitis patients

IF 0.2 Q4 OTORHINOLARYNGOLOGY ENT Updates Pub Date : 2019-08-01 DOI:10.32448/ENTUPDATES.581445
D. Yazici
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Abstract

Objectives: The aim of this study is to assess neutrophil-lymphocyte ratio (NLR), mean platelet volume (MPV), platelet-lymphocyte ratio (PLR) and eosinophil-lymphocyte ratio (ELR) of allergic rhinitis patients and compare our findings with healthy controls. We also analyzed the effect of severity of allergic rhinitis on hematological parameters and total IgE levels of the patients. Methods: A total of forty-six patients diagnosed having allergic rhinitis according to Allergic Rhinitis and its Impact on Asthma (ARIA) criteria and forty-six healthy, age and sex-matched subjects were included in this study. The clinical records of the patients were retrospectively analyzed and age, gender, skin prick test results, complete blood counts, total IgE levels and Sino-Nasal Outcome Test (SNOT) 22 scores were recorded for assessment of neutrophil-lymphocyte ratio (NLR), mean platelet volume (MPV), platelet-lymphocyte ratio (PLR) and eosinophil-lymphocyte ratio (ELR) of the patients. Results: Eosinophil count, eosinophil percentage and ELR value of the study group were significantly higher than the control group. (p=0,001, p=0,001, p=0,001 respectively) The cut-off value for ELR was ≥0,105. (sensitivity=0,61, specificity=0,76, AUC=0,703) Total IgE levels of patients with positive skin prick test were significantly higher than patients with negative skin prick test. (p=0,019) The cut-off value for total IgE was ≥63 IU/mL. (sensitivity=0,59, specificity=0,74, AUC=0,706). Conclusion: ELR is a valuable marker for predicting allergic rhinitis. However, it does not correlate with the severity of the disease. Total IgE levels increase in patients with positive skin prick tests. Also, total IgE level does not correlate with the severity of allergic rhinitis.
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变应性鼻炎患者炎症生物标志物、总IgE水平、SNOT-22评分的评估
目的:评价变应性鼻炎患者的中性粒细胞-淋巴细胞比率(NLR)、平均血小板体积(MPV)、血小板-淋巴细胞比率(PLR)和嗜酸性粒细胞-淋巴细胞比率(ELR),并与健康对照进行比较。我们还分析了变应性鼻炎严重程度对患者血液学参数和总IgE水平的影响。方法:根据变态反应性鼻炎及其对哮喘的影响(ARIA)标准诊断为变态反应性鼻炎的患者46例,年龄和性别匹配的健康受试者46例。回顾性分析患者的临床资料,记录患者的年龄、性别、皮肤点刺试验结果、全血计数、总IgE水平和鼻鼻预后试验(SNOT) 22评分,评估患者的中性粒细胞-淋巴细胞比(NLR)、平均血小板体积(MPV)、血小板-淋巴细胞比(PLR)和嗜酸性粒细胞-淋巴细胞比(ELR)。结果:研究组嗜酸性粒细胞计数、嗜酸性粒细胞百分比及ELR值均显著高于对照组。(p=0,001, p=0,001, p=0,001) ELR的临界值≥0,105。(敏感性=0,61,特异性=0,76,AUC=0,703)皮刺试验阳性患者总IgE水平显著高于皮刺试验阴性患者。(p= 0.019)总IgE临界值≥63 IU/mL。(灵敏度=0,59,特异性=0,74,AUC=0,706)。结论:ELR是预测变应性鼻炎的重要指标。然而,它与疾病的严重程度无关。皮肤点刺试验阳性患者总IgE水平升高。此外,总IgE水平与变应性鼻炎的严重程度无关。
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来源期刊
ENT Updates
ENT Updates OTORHINOLARYNGOLOGY-
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