The Oscillating Gut Microbiome and Its Effects on Host Circadian Biology.

IF 12.6 2区 医学 Q1 NUTRITION & DIETETICS Annual review of nutrition Pub Date : 2022-05-16 DOI:10.1146/annurev-nutr-062320-111321
Lev Litichevskiy, Christoph A. Thaiss
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引用次数: 12

Abstract

The microbial community colonizing the gastrointestinal tract, collectively termed the gut microbiota, is an important element of the host organism due to its impact on multiple aspects of health. The digestion of food, secretion of immunostimulatory molecules, performance of chemical reactions in the intestine, and production of metabolites by the microbiota contribute to host homeostasis and disease. Recent discoveries indicate that these major functions are not constantly performed over the course of a day, but rather undergo diurnal fluctuations due to compositional and biogeographical oscillations in the microbiota. Here, we summarize the characteristics and origins of diurnal microbiome rhythms as well as their functional consequences for the circadian biology of the host. We describe the major known pathways of circadian host-microbiome communication and discuss possible implications of altered diurnal microbiome rhythms for human disease. Expected final online publication date for the Annual Review of Nutrition, Volume 42 is August 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
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振荡肠道微生物组及其对宿主昼夜生物学的影响。
定殖在胃肠道的微生物群落,统称为肠道微生物群,由于其对健康的多个方面的影响,是宿主生物的重要组成部分。食物的消化、免疫刺激分子的分泌、肠道中化学反应的表现以及微生物群产生代谢产物有助于宿主体内平衡和疾病。最近的发现表明,这些主要功能并不是在一天中不断发挥的,而是由于微生物群的组成和生物地理振荡而发生的昼夜波动。在这里,我们总结了昼夜微生物组节律的特征和起源,以及它们对宿主昼夜生物学的功能影响。我们描述了昼夜节律宿主-微生物组交流的主要已知途径,并讨论了昼夜节律改变对人类疾病的可能影响。《营养年度评论》第42卷预计最终在线出版日期为2022年8月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual review of nutrition
Annual review of nutrition 医学-营养学
CiteScore
15.80
自引率
0.00%
发文量
19
期刊介绍: Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition
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