Zika virus disease in pregnancy and associated fetal neurological complications – a descriptive review

Q4 Medicine Revista Romana de Pediatrie Pub Date : 2022-11-30 DOI:10.37897/rjp.2022.s2.14
R. Bors, Maria Anghelache, M. Ciocârlan, Vlad Dima, M. Plotogea, V. Varlas
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Abstract

Zika virus is a flavivirus transmitted mainly by Aedes mosquitoes, and pregnant women are usually asymptomatic or have non-specific symptoms. The virus can cross the placental barrier and is intensely neurotropic, with destructive and malformative consequences on the fetal central nervous system, causing a series of severe abnormalities in infected fetuses in the first trimester, more severe than in TORCH infections. Viral infection can be suspected during ultrasound screening by highlighting severe microcephaly and macroscopic calcifications in the fetal brain. In addition, auditory, ocular, or musculoskeletal abnormalities have been reported. Prophylaxis of infection in pregnant women is essential due to the increased risk of fetal damage currently, there is no vaccine or approved treatment.
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妊娠期寨卡病毒病及相关胎儿神经系统并发症的描述性综述
寨卡病毒是一种主要由伊蚊传播的黄病毒,孕妇通常无症状或有非特异性症状。该病毒可以穿过胎盘屏障,具有强烈的嗜神经性,对胎儿中枢神经系统具有破坏性和畸形后果,在妊娠早期感染胎儿时会导致一系列严重异常,比TORCH感染更严重。在超声筛查过程中,可以通过突出胎儿大脑中严重的小头畸形和宏观钙化来怀疑病毒感染。此外,还报告了听觉、眼部或肌肉骨骼异常。由于胎儿损伤的风险增加,预防孕妇感染至关重要。目前,还没有疫苗或批准的治疗方法。
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CiteScore
0.10
自引率
0.00%
发文量
15
审稿时长
4 weeks
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