Synthesis of Acidiphilamide A–C: Secondary Metabolites from the Genus Streptacidiphilus

Abstract

The paper describes the efficient total syntheses of naturally occurring tripeptides Acidiphilamides A–C and epi-Acidiphilamides A-C, which were prepared from commercially available L-phenyl alanine using Hexafluorophosphate Azabenzotriazole Tetramethyl Uronium (HATU) as peptide coupling reagent. The structures of the natural Acidiphilamides A, B and C were characterized by NMR, MS & SOR data which were matching with those of natural products, whereas the structures of epi-Acidiphilamides A, B and C were confirmed by 2D NMR studies.