Depression and Suicidality of Intranasal Ketamine: Current Evidence

Abstract

Repeated use of IV ketamine infusion for depression and suicidality is not practical for some of patients. Thus, the objective of this report is to describe the current and forthcoming trials investigating Intranasal (IN) ketamine. We conducted a search of PubMed and clinical trials. Gov. There is one published, randomized, double-blind trial and five clinical trials in clinicaltrials.gov: two completed, two recruiting, and one withdrawn. IN ketamine is potentially a promising and practical alternative to IV infusion. Data is still limited, however the results of these ongoing studies could provide helpful clinical guidance regarding efficacy and adverse effects.