Angiotensin II Type 1 Receptor‐Mediated Hypothalamic Paraventricular Nucleus Neuroinflammation And Blood Brain Barrier Disruption Contribute To Age‐Dependent Hypertension In Male, But Not Female, Sprague Dawley Rats
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Abstract
Aging is a risk factor for the development of hypertension. Recently, neuroinflammation in cardio‐regulatory centers of the brain, specifically the hypothalamic paraventricular nucleus (PVN), has been identified as a potential driver of hypertension via sympathetically‐mediated mechanisms. We hypothesize neuroinflammatory mechanisms contribute to the progression of age‐dependent hypertension.
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