{"title":"Review of mechanisms of genotoxic action of dibenzo[def,p]chrysene (formerly dibenzo[a,l]pyrene)","authors":"K. Kowalczyk, J. Roszak, Z. Sobańska, M. Stępnik","doi":"10.1080/15569543.2022.2124419","DOIUrl":null,"url":null,"abstract":"Abstract Polycyclic aromatic hydrocarbons (PAHs) are a large group of organic compounds that have always been present in the environment. With the technological and civilization development, exposure to this class of compounds has considerably increased. Dibenzo[def,p]chrysene (DBC), formerly known as dibenzo[a,l]pyrene, is one of the most important and probably the most carcinogenic among all PAHs tested so far. Its carcinogenic and mutagenic effects on mammalian cell systems and animals have been documented, and hence it was classified as “possibly carcinogenic to humans.” This review presents the most important aspects of mechanisms of genotoxicity after exposure to DBC.","PeriodicalId":23211,"journal":{"name":"Toxin Reviews","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxin Reviews","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/15569543.2022.2124419","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Abstract Polycyclic aromatic hydrocarbons (PAHs) are a large group of organic compounds that have always been present in the environment. With the technological and civilization development, exposure to this class of compounds has considerably increased. Dibenzo[def,p]chrysene (DBC), formerly known as dibenzo[a,l]pyrene, is one of the most important and probably the most carcinogenic among all PAHs tested so far. Its carcinogenic and mutagenic effects on mammalian cell systems and animals have been documented, and hence it was classified as “possibly carcinogenic to humans.” This review presents the most important aspects of mechanisms of genotoxicity after exposure to DBC.
期刊介绍：
Toxin Reviews provides an international forum for publishing state-of-the-art reviews and guest-edited single topic special issues covering the multidisciplinary research in the area of toxins derived from animals, plants and microorganisms. Our aim is to publish reviews that are of broad interest and importance to the toxinology as well as other life science communities. Toxin Reviews aims to encourage scientists to highlight the contribution of toxins as research tools in deciphering molecular and cellular mechanisms, and as prototypes of therapeutic agents. Reviews should emphasize the role of toxins in enhancing our fundamental understanding of life sciences, protein chemistry, structural biology, pharmacology, clinical toxinology and evolution. Prominence will be given to reviews that propose new ideas or approaches and further the knowledge of toxinology.
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