O. Kazakova, L. Rubanik, I. Smirnova, O. Savinova, A. Petrova, N. Poleschuk, E. Khusnutdinova, E. Boreko, Yu. M. Kapustina
{"title":"Synthesis and in vitro activity of oleanane type derivatives against Chlamydia trachomatis","authors":"O. Kazakova, L. Rubanik, I. Smirnova, O. Savinova, A. Petrova, N. Poleschuk, E. Khusnutdinova, E. Boreko, Yu. M. Kapustina","doi":"10.25135/acg.oc.66.19.07.1352","DOIUrl":null,"url":null,"abstract":"Modified synthesis of 3β-nicotinoyloxy-olean-12(13)-en-28-oic acid and 3-deoxy-3a-homo-3a-aza28-hydroxy-olean-12(13)-ene from natural occurring oleanolic acid is suggested. These compounds and two others of ursane and lupane type triterpenoids (3-oximino-urs-12-en-28-oic acid and 3-deoxy-3a-homo-3a-aza28-hydroxy-lup-12(13)-ene) were screened in vitro against Chlamydia trachomatis strain F-3271/Belarus/2015. Oleanane triterpenoids became the leading compounds with chemotherapeutic index > 8 and were chosen for further research.","PeriodicalId":19553,"journal":{"name":"Organic Communications","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25135/acg.oc.66.19.07.1352","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 9
Abstract
Modified synthesis of 3β-nicotinoyloxy-olean-12(13)-en-28-oic acid and 3-deoxy-3a-homo-3a-aza28-hydroxy-olean-12(13)-ene from natural occurring oleanolic acid is suggested. These compounds and two others of ursane and lupane type triterpenoids (3-oximino-urs-12-en-28-oic acid and 3-deoxy-3a-homo-3a-aza28-hydroxy-lup-12(13)-ene) were screened in vitro against Chlamydia trachomatis strain F-3271/Belarus/2015. Oleanane triterpenoids became the leading compounds with chemotherapeutic index > 8 and were chosen for further research.
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