Continuous Moderate Exercise Influence on Cardiac Remodeling in Patients Underwent Percutaneous Coronary Intervention

Abstract

Background: Following myocardial infarction (MI), left ventricle (LV) remodeling is a complex and multifactorial mechanism with therapeutic and prognostic consequences. Medications that reduce LV remodeling increase survival and quality of life. Exercising following a myocardial infarction (MI) is effective according to several trials. The implications on operation and remodeling, however, are still debated Aim of work: To evaluate continuous moderate-intensity aerobic training effects by using cardiac magnetic resonance imaging on left ventricular remodeling after one month of percutaneous coronary intervention (PCI) following myocardial infarction. Methods: Forty eligible patients (5 females and 35 males) who had PCI after one month of having MI with age 45-65 years old. They underwent conventional medical treatment in addition to a supervised intensive recovery regimen that included 36 hours of continuous moderate aerobic exercise (three times /week for 12 weeks). Evaluation of the effect of this program was done by magnetic resonance imaging (CMR) to calculate EF. Result: This research was done on 40 patients (5 females and 35 males) who had PCI after myocardial infarction. The mean age of the participants was 54.1 ± 7.0. Most patients have Killip class I. LAD was the culprit artery in 70% of the patients. The most common risk factors were smoking, dyslipidemia, and overweight. Post-treatment BMI decreased compared with pre-treatment BMI (p <0.05) for an improvement average of 5.37 percent. There was also a substantial improvement in the pretreatment systolic blood pressure and functional parameters as compared for post-treatment (p<0.05). As regard cardiac MRI, There was a significant reduction in post-treatment LV mass (117.2 ± 27.2) relative to pretreatment (128.7 ± 38.9). EF % was marked improvement from 49.32 ± 5.12 to 56.63 ± 5.49 (P value < 000.1). EDV and all other parameters show marked improvement post treatment as compared to pretreatment. Conclusion: Moderate-intensity aerobic exercise improved LV remodeling after percutaneous coronary intervention (PCI) one month following myocardial Infarction.