Association of Mannose-Binding Lectin Gene Polymorphisms with Liver Diseases: A Review

Robert S. Lo, A. Austin, J. Freeman
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Abstract

Mannose-Binding Lectin (MBL) is a member of the collectin family and is an important protein in the immune system. It is a pathogen pattern-recognition molecule that binds to specific carbohydrate motifs on the surface of many pathogens. MBL activates complement via lectin pathway. Single nucleotide polymorphisms in the MBL gene influence serum MBL concentration and function. MBL deficiencies increase the risk of infection and disease-specific complications, especially in those who are already immune compromised with pre-existing conditions. This review discusses the molecular genetics of human MBL and the association of MBL polymorphisms with liver diseases including liver fibrosis, viral hepatitis B, viral hepatitis C, and infection post-liver transplantation.
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甘露糖结合凝集素基因多态性与肝病的关系
甘露糖结合凝集素(MBL)是凝集素家族的一员,是免疫系统中的一种重要蛋白质。它是一种病原体模式识别分子,与许多病原体表面的特定碳水化合物基序结合。MBL通过凝集素途径激活补体。MBL基因单核苷酸多态性影响血清MBL浓度和功能。MBL缺乏会增加感染和疾病特异性并发症的风险,尤其是那些已经因先前存在的疾病而免疫受损的人。本文综述了人MBL的分子遗传学以及MBL多态性与肝纤维化、乙型病毒性肝炎、丙型病毒性肝炎和肝移植后感染等肝脏疾病的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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