Sildenafil citrate effects on seminal parameters in male participants with idiopathic infertility; A randomized, double-blind, controlled cross-over clinical trial study

IF 0.8 Q4 UROLOGY & NEPHROLOGY Urological Science Pub Date : 2022-04-01 DOI:10.4103/uros.uros_113_21
Gh R Mokhtari, A. Madani, E. Leyli, A. Jafari
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引用次数: 1

Abstract

Purpose: Sildenafil is a phosphodiesterase Type 5 inhibitor, which is a powerful and effective therapy for male erectile dysfunction (ED) and enables to restore temporary ED. The aim of this study was to evaluate the effects of sildenafil on seminal parameters in male participants with idiopathic infertility. Materials and Methods: This randomized, double-blind, controlled cross-over clinical trial study was conducted on 79 participants who had been referred to urology clinics in Rasht. Participants were assigned to two Groups A (n = 40), and B (n = 39). In Phase I, participants in Group A received a pill of sildenafil (50 mg) and then received a pill of placebo after the washout period, and participants in Group B received a pill of placebo and then received a pill of sildenafil after the washout period. In Phase II, participants in Group A received a pill of placebo and then received a pill of sildenafil after the washout period; and participants in group B received sildenafil and then received a placebo after the washout period. Results: The mean age of patients was 34 ± 5 years. There was no significant difference in the mean sperm count before receiving the drug in all groups. Sperm count, motility, morphology, pH, viscosity, and liquefaction time of semen did not significantly change after receiving sildenafil in comparison to their corresponding placebo group (P > 0.05). Conclusion: Sildenafil did not change sperm parameters in treating infertile patients; sildenafil also had no positive effect on semen parameters.
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柠檬酸西地那非对男性特发性不育症患者精液参数的影响一项随机、双盲、对照交叉临床试验研究
目的:西地那非是一种磷酸二酯酶5型抑制剂,是一种治疗男性勃起功能障碍(ED)的强效有效药物,能够恢复暂时性ED。本研究的目的是评估西地那非对特发性不孕男性参与者精液参数的影响。材料和方法:这项随机、双盲、对照的交叉临床试验研究对79名被转诊到拉什特泌尿外科诊所的参与者进行。参与者被分为A组(n=40)和B组(n=39)。在第一阶段,A组的参与者服用一片西地那非(50 mg),然后在洗脱期后服用一片安慰剂,B组的参与者则服用一片安慰药,然后在洗脱期后接受一片西地那非。在第二阶段,A组的参与者服用一片安慰剂,然后在洗脱期后服用一片西地那非;B组的参与者接受西地那非,然后在冲洗期后接受安慰剂。结果:患者平均年龄34±5岁。所有组在接受药物治疗前的平均精子数没有显著差异。与安慰剂组相比,接受西地那非治疗后,精液的精子计数、活力、形态、pH、粘度和液化时间没有显著变化(P>0.05);西地那非对精液参数也没有积极影响。
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来源期刊
Urological Science
Urological Science UROLOGY & NEPHROLOGY-
CiteScore
1.20
自引率
0.00%
发文量
26
审稿时长
6 weeks
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