Nano-antivirals: A comprehensive review

IF 4.1 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Frontiers in Nanotechnology Pub Date : 2022-12-13 DOI:10.3389/fnano.2022.1064615

F. Hussain, Naveed Qasim Abro, N. Ahmed, S. Memon, Najma Memon

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引用次数: 5

Abstract

Nanoparticles can be used as inhibitory agents against various microorganisms, including bacteria, algae, archaea, fungi, and a huge class of viruses. The mechanism of action includes inhibiting the function of the cell membrane/stopping the synthesis of the cell membrane, disturbing the transduction of energy, producing toxic reactive oxygen species (ROS), and inhibiting or reducing RNA and DNA production. Various nanomaterials, including different metallic, silicon, and carbon-based nanomaterials and nanoarchitectures, have been successfully used against different viruses. Recent research strongly agrees that these nanoarchitecture-based virucidal materials (nano-antivirals) have shown activity in the solid state. Therefore, they are very useful in the development of several products, such as fabric and high-touch surfaces. This review thoroughly and critically identifies recently developed nano-antivirals and their products, nano-antiviral deposition methods on various substrates, and possible mechanisms of action. By considering the commercial viability of nano-antivirals, recommendations are made to develop scalable and sustainable nano-antiviral products with contact-killing properties. Graphical Abstract

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纳米抗病毒药物：综述

纳米粒子可以用作各种微生物的抑制剂，包括细菌、藻类、古菌、真菌和一大类病毒。作用机制包括抑制细胞膜的功能/停止细胞膜的合成，干扰能量的转导，产生有毒的活性氧（ROS），以及抑制或减少RNA和DNA的产生。各种纳米材料，包括不同的金属、硅和碳基纳米材料和纳米结构，已成功用于对抗不同的病毒。最近的研究强烈认为，这些基于纳米结构的杀病毒材料（纳米抗病毒药物）在固态下显示出活性。因此，它们在一些产品的开发中非常有用，例如织物和高接触表面。这篇综述全面而批判性地确定了最近开发的纳米抗病毒药物及其产品，在各种基质上的纳米抗病毒沉积方法，以及可能的作用机制。通过考虑纳米抗病毒药物的商业可行性，建议开发具有接触杀伤特性的可扩展和可持续的纳米抗病毒产品。图形摘要

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