The effect of extract purple sweet drop on nuclear factor kappa B and amyloid deposits in D-galactose induced dementia in rats

Abstract

Background. Alzheimer’s dementia (AD) as a neurodegenerative disease requires preventive measures to reduce its progression. Beta amyloid plaques induce chronic inflammation and apoptosis in AD. Anthocyanins in purple sweet potato are potential for prevention and therapy of AD. Aim. This study aimed to determine the role of anthocyanins in purple sweet potato extract to prevent inflammation so as to provide a neuroprotective effect on D-galactose-induced rats. Material and methods. We used a randomized posttest only control group design. 32 male Wistar rats according to eligibility criteria were randomized into control and treatment groups. The treatment group was given purple sweet potato extract at a dose of 200mg/kgBW every day for 70 days. Both groups on day 15 induced dementia using D-galactose. Anti-inflammatory activity was evaluated from the examination of NFkB levels by ELISA technique and neuroprotective effects by immunohistochemical examination of amyloid plaque deposits. Results. The mean NFkB of the treatment group (1417.55+255.82) was lower than the control group (1672.23+202.80) which was significant (p<0.05) and the amyloid plaque deposits in the treatment group were thinner than the control group. Conclusions. Administration of purple sweet potato extract to D-galactose-induced rats caused lower NFkB levels and thinner amyloid plaque deposits. The research implication is that administration of purple sweet potato extract can prevent inflammation and provide neuroprotection effects in D-galactose-induced rats.