Effect of Ajwa date seed powder on visceral fat depots and inflammatory response in high fat fed Sprague Dawley female rats.

Farhana Yasmin Bhatti, Fariha Ahmad Khan, A. M. Rehan, Zoobia Irum, Sadia Chiragh
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Abstract

ABSTRACT Background: Central obesity a worldwide metabolic and cosmetic problem poses significant health risk. Ajwa date seed has antioxidant property and its high fiber content may prevent fat absorption and reduce fat deposition. Objective: To evaluate the effect of Ajwa date seed powder on visceral fat depots and inflammatory response in high fat fed Sprague Dawley female rats. Methodology: Thirty-six healthy rats of four weeks age were divided into three groups and followed for 12 weeks. Group A (normal control) received regular diet. Group B (HFD control) received high fat diet, while group C (HFD+Ajwa group) received high fat diet along with 2% Ajwa date seed powder. Body weight was measured weekly. Blood sample was drawn for the estimation of serum IL-6 and leptin levels by ELISA method at 12th week. After which rats were euthanized; perinephric fat was removed and weighed in grams. Results: HFD+Ajwa group gained less body weight as compared to HFD control group (p value = 0.012). There was a remarkable reduction in perinephric fat weight (p value ≤ 0.001) and level of IL-6 in HFD+Ajwa group (p value ≤ 0.001) as compared to HFD control. There was no significant difference in serum leptin level of the rats of all groups (p value = 0.567). Conclusion: Ajwa date seed can prevent visceral adiposity and gain in body weight. Moreover, it has anti-inflammatory effect; but no significant effect on satiety hormone. Key Words: Obesity, Visceral fat, P. dactylifera L (Ajwa date) seed, IL-6, Leptin.
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枣籽粉对高脂喂养Sprague Dawley雌性大鼠内脏脂肪储存及炎症反应的影响。
摘要背景:中心性肥胖是一个全球性的代谢和美容问题,对健康构成重大风险。Ajwa枣种子具有抗氧化性能,其高纤维含量可以防止脂肪吸收和减少脂肪沉积。目的:评价阿杰瓦枣籽粉对高脂喂养Sprague-Dawley雌性大鼠内脏脂肪库和炎症反应的影响。方法:将36只4周龄的健康大鼠分为3组,随访12周。A组(正常对照组)常规饮食。B组(HFD对照组)接受高脂肪饮食,而C组(HFD+Ajwa组)接受含2%Ajwa椰枣籽粉的高脂肪饮食。每周测量体重。第12周抽取血样,用ELISA法测定血清IL-6和瘦素水平。之后对大鼠实施安乐死;去除肾周脂肪,并以克为单位称重。结果:与HFD对照组相比,HFD+Ajwa组的体重增加较少(p值=0.012)。与HFD控制组相比,肾周脂肪重量(p值≤0.001)和IL-6水平显著降低(p值<0.001)。各组大鼠血清瘦素水平无显著性差异(p值=0.567)。此外,它还具有抗炎作用;但对饱腹激素无明显影响。关键词:肥胖,内脏脂肪,鸭舌兰种子,IL-6,瘦素。
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发文量
35
审稿时长
16 weeks
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