Influence of cardiopulmonary bypass on postoperative brain cognitive function of children with congenital heart disease

Q4 Medicine 中华实用儿科临床杂志 Pub Date : 2020-01-05 DOI:10.3760/CMA.J.ISSN.2095-428X.2020.01.019

K. Xiang, Haisong Bu, Jiarong Li

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Abstract

Congenital heart disease (CHD) is the most common congenital malformation disease in infants.With the rapid development of clinical treatment, the survival rate of children with CHD increased significantly.However, postoperative complications in children with CHD, including heart failure, heart arrythmia, pulmonary hypertension and brain cognitive dysfunction, are another challenge, among which, brain cognitive dysfunction has been gradually recognized and valued by scholars.At present, the effect of cardiopulmonary bypass on brain cognitive function of children with CHD has been studied by a variety of research methods, including molecular biological technique, magnetic resonance imaging technique, optical imaging technology, brain electrical activity monitoring technology and nervous development scale.Varying degrees of brain cognitive dysfunction will occur in children with CHD after heart surgery, which is closely associated with many factors such as systemic inflammatory response related to cardiopulmonary bypass, cerebral ischemia-reperfustion injury, the duration of cardiopulmonary bypass, aortic cross clamp time, deep hypothermia circulatory arrest time, dynamic changes of temperature, degree of hemodilution and blood gas management strategy.The influence of cardiopulmonary bypass on postoperative brain cognitive function in children with CHD is reviewed in this paper, in order to provide reference for clinical diagnosis and treatment, and to improve the prognosis of children with CHD. Key words: Cardiopulmonary bypass; Brain cognitive function; Congenital heart disease

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体外循环对先天性心脏病患儿术后大脑认知功能的影响

先天性心脏病(CHD)是婴幼儿最常见的先天性畸形疾病。随着临床治疗的快速发展，儿童冠心病的生存率显著提高。然而，儿童冠心病的术后并发症，包括心力衰竭、心律失常、肺动脉高压和脑认知功能障碍是另一个挑战，其中脑认知功能障碍已逐渐被学者们所认识和重视。目前，通过分子生物学技术、磁共振成像技术、光学成像技术、脑电活动监测技术、神经发育量表等多种研究方法研究体外循环对冠心病儿童脑认知功能的影响。冠心病患儿心脏手术后会出现不同程度的脑认知功能障碍，这与体外循环相关的全身炎症反应、脑缺血再灌注损伤、体外循环持续时间、主动脉交叉夹持时间、深低温循环停搏时间、体温动态变化、血液稀释程度、血气管理策略等诸多因素密切相关。本文就体外循环对冠心病患儿术后脑认知功能的影响进行综述，以期为临床诊断和治疗提供参考，改善冠心病患儿预后。关键词:体外循环;脑认知功能;先天性心脏病

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来源期刊

中华实用儿科临床杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.60

自引率

0.00%

发文量

14243

期刊介绍： Chinese Journal of Applied Clinical Pediatrics ( semi-monthly ) is a core journal of paediatrics under the supervision of China Association for Science and Technology, sponsored by Chinese Medical Association and undertaken by Xinxiang Medical College. Founded in 1986, it is openly circulated both at home and abroad. The journal has several columns, such as Expert Forum, Experimental Research and Paediatric Surgery, which are mainly for paediatric medical workers and medical researchers in hospitals. Its purpose is to reflect the new theories and technologies in paediatric medicine and scientific research at home and abroad, and to promote academic exchanges. Chinese Journal of Applied Clinical Pediatrics is a source journal of China Science Citation Database (CSCD), a core journal of Peking University, a source journal of Chinese science and technology paper statistics (China Science and Technology Core Journals), a core academic journal of RCCSE, a high-quality scientific and technical journal of China, a high-quality scientific and technical journal of China Association for Science and Technology, and a high-quality scientific and technical journal of China Biomedical Science and Technology Association. We have been published in China Biomedical Literature Database (SinoMed), China Knowledge Network, Wanfang Data Knowledge Service Platform, China Academic Journal Abstracts, Scopus Database, Chemical Abstracts (USA), Japan Science and Technology Agency (JSTA) Database, Copernicus Abstracts (Poland), Abstracts of the Centre for Agricultural and Biological Sciences (CABS) of the United Kingdom, Cambridge Scientific Abstracts ProQuest Database, WHO Medical Journal of the Western Pacific Region (WMPR), and WHO Medical Journal of the Western Pacific Region (WMPR) of the United States. We have been included in dozens of authoritative databases at home and abroad, such as WHO Western Pacific Region Index of Medicine (WPRIM), Ullrich's Guide to Periodicals, and so on.