Paracetamol Overdose May Cause Transudative Pleural Effusion in Adults

IF 0.1 Q4 EMERGENCY MEDICINE Journal of Emergency Medicine Case Reports Pub Date : 2021-01-27 DOI:10.33706/JEMCR.834306
I. Akbas, A. Koçak, S. Utlu, S. Doğruyol, Z. Çakır
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Abstract

Paracetamol is the most widely used and prescribed drug word-wide. It is the most common cause of the poisoning and of the fatality due to the toxic administration throughout the world. A 34-year-old female patient applied to our ED with the complaint of swallowing 33 g of paracetamol. After routine toxicity treatment, on the third day of the hospitalization, dyspnea and pain on the right hemithorax and right flank occurred. Chest X-ray showed blunted right sinus. CT revealed bilateral pleural effusion. With thoracentesis, clear, colorless and odor-free fluid of about 500cc was drained. Laboratory examination of the fluid confirmed it as transudate. We believed pleural effusion is related to high-dose paracetamol intake and it occurred due to decrease in pleural permeability and the consequent decrease of the fluid absorption. In conclusion, high-dose intake of paracetamol might cause transudative pleural effusion as a complication.
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对乙酰氨基酚过量可引起成人胸腔积液
扑热息痛是世界上使用最广泛的处方药。它是中毒和死亡的最常见的原因,由于世界各地的有毒管理。一名34岁女性患者就诊于急诊科,主诉吞咽33克扑热息痛。常规毒理治疗后,住院第3天出现呼吸困难,右侧半胸、右侧胁部疼痛。胸部x光片显示右鼻窦钝化。CT示双侧胸腔积液。胸腔穿刺排出500cc左右透明、无色、无臭的液体。对液体的化验证实是渗出物。我们认为胸腔积液与大剂量扑热息痛摄入有关,其发生是由于胸膜通透性降低,从而导致液体吸收减少。综上所述,大剂量摄入扑热息痛可能导致胸腔积液的并发症。
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