Relationship Between Multiple Sclerosis, Gut Dysbiosis, and Inflammation

IF 2.4 4区 医学 Q2 CLINICAL NEUROLOGY Neurologic Clinics Pub Date : 2023-08-30 DOI:10.1016/j.ncl.2023.07.005
Larissa Jank MD, Pavan Bhargava MD
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多发性硬化症、肠道生态失调和炎症的关系
多发性硬化症与肠道生态失调有关,其特征是特定微生物的相对丰度、循环肠道衍生代谢物和肠道通透性的改变。这种肠道生态失调通过增加循环促炎细菌因子、减少耐受性因子、诱导分子模仿和改变微生物营养代谢来促进疾病病理。有益的抗炎作用的微生物组可以利用在治疗干预。在未来,有必要在随机对照临床试验中评估这些疗法的疗效,以帮助使饮食和肠道生态失调管理成为多发性硬化症治疗的一个组成部分。
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来源期刊
Neurologic Clinics
Neurologic Clinics 医学-临床神经学
CiteScore
5.00
自引率
4.20%
发文量
92
审稿时长
6-12 weeks
期刊介绍: Targeted toward those in the fields of neurology, family medicine, otolaryngology, and pediatrics, Neurologic Clinics offers a broad view of current practice, as well as the evidence to support it. Published quarterly — in February, May, August, and November — each issue focuses on a single topic neurology, including hearing loss, cholesteatoma, rhinology, anosmia, dysphagia, and pediatric-specific ENT.
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