Jinglin Huang, Minjie Zhou, Le Wei, Chen Guo, Shuang Ni, Niu Gao, L. Zeyu, Zongqin Zhao, Zhibing He, Li Bo, Song-nan Zhao, Bao-Han Zhang, Du Kai
{"title":"Detection of spike protein of SARS-CoV-2 by surface enhanced Raman spectroscopy","authors":"Jinglin Huang, Minjie Zhou, Le Wei, Chen Guo, Shuang Ni, Niu Gao, L. Zeyu, Zongqin Zhao, Zhibing He, Li Bo, Song-nan Zhao, Bao-Han Zhang, Du Kai","doi":"10.11884/HPLPB202032.200145","DOIUrl":null,"url":null,"abstract":"The development of rapid detection technique with high sensitivity and high veracity for SARS-CoV-2 is of great importance for the prevention and control of epidemic. In this work, the trace spike protein (S protein) of SARS-CoV-2 in human saliva was detected by surface enhanced Raman spectroscopy (SERS) technique. Significant differences can be found between the Raman spectra of the S protein stained saliva sample and the primitive saliva sample. These results will lay the foundation for the future rapid detection of SARS-CoV-2 by SERS technique.","PeriodicalId":39871,"journal":{"name":"强激光与粒子束","volume":"32 1","pages":"069001-1-069001-2"},"PeriodicalIF":0.0000,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"强激光与粒子束","FirstCategoryId":"1089","ListUrlMain":"https://doi.org/10.11884/HPLPB202032.200145","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Engineering","Score":null,"Total":0}
引用次数: 5
Abstract
The development of rapid detection technique with high sensitivity and high veracity for SARS-CoV-2 is of great importance for the prevention and control of epidemic. In this work, the trace spike protein (S protein) of SARS-CoV-2 in human saliva was detected by surface enhanced Raman spectroscopy (SERS) technique. Significant differences can be found between the Raman spectra of the S protein stained saliva sample and the primitive saliva sample. These results will lay the foundation for the future rapid detection of SARS-CoV-2 by SERS technique.