{"title":"Expression of chimeric genes in bone marrow cells of children with acute lymphoblastic leukemia upon cytostatic therapy","authors":"O. Vynnytska, L. Dubey, D. Halytsky","doi":"10.7124/bc.000a70","DOIUrl":null,"url":null,"abstract":"Aim. To study the expression of chimeric genes in bone marrow cells as prognostic factors of the course of acute lymphoblastic leukemia (ALL) in children and [to] evaluate their role in resistance to cytostatic chemotherapy. Methods. The AF4-MLL, BCR-ABL, E2A-RVX, TEL-AML1 c himeric gene expression level was determined by RT-qPCR. Results. The AF4-MLL oncogene was not expressed in children during remission, and the expression of all other studied oncogenes was at a low level. In conditions of relapse, there was no expression of the TEL-AML oncogene and a high expression of the BCR-ABL. Conclusions. The Development, course, and survival of ALL patients largely depend on the expression of AF4-MLL, BCR-ABL, E2A-PBX1, TEL-AML chimeric genes in the bone marrow; this should be taken into account when detecting early relapses in patients after chemotherapy.","PeriodicalId":39444,"journal":{"name":"Biopolymers and Cell","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biopolymers and Cell","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7124/bc.000a70","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Aim. To study the expression of chimeric genes in bone marrow cells as prognostic factors of the course of acute lymphoblastic leukemia (ALL) in children and [to] evaluate their role in resistance to cytostatic chemotherapy. Methods. The AF4-MLL, BCR-ABL, E2A-RVX, TEL-AML1 c himeric gene expression level was determined by RT-qPCR. Results. The AF4-MLL oncogene was not expressed in children during remission, and the expression of all other studied oncogenes was at a low level. In conditions of relapse, there was no expression of the TEL-AML oncogene and a high expression of the BCR-ABL. Conclusions. The Development, course, and survival of ALL patients largely depend on the expression of AF4-MLL, BCR-ABL, E2A-PBX1, TEL-AML chimeric genes in the bone marrow; this should be taken into account when detecting early relapses in patients after chemotherapy.
Biopolymers and CellBiochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
1.10
自引率
0.00%
发文量
9
期刊介绍：
“Biopolymer and cell” is published since 1985 at the Institute of Molecular Biology and Genetics NAS of Ukraine under the supervision of the National Academy of Sciences of Ukraine. Our journal covers a wide scope of problems related to molecular biology and genetics including structural and functional genomics, transcriptomics, proteomics, bioinformatics, biomedicine, molecular enzymology, molecular virology and immunology, theoretical bases of biotechnology, physics and physical chemistry of proteins and nucleic acids and bioorganic chemistry.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
