Clinical Evaluation of Honey Throat Spray for Auxiliary Treatment of Pharyngitis

Davar Nikzadeh Kigal, S. Habibzadeh, H. Ebrahimi, Masoumeh Mohammadi Monfared, Mansour Miran
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Abstract

Background & objectives: Due to the increasing prevalence of bacterial resistance, there is a growing attention to application of auxiliary treatment of pharyngitis. The aim of this study was to investigate the effect of honey throat spray in the auxiliary treatment of patients with a diagnosis of pharyngitis. Methods: At the start, different physicochemical quality parameters of the honey sample were evaluated. Then, the bottles of honey and the placebo throat spray were prepared. The numbers of 70 patients with the diagnosis of pharyngitis were included in a one-step and double-blinded study. In addition to standard treatment, each patient received either one of the honey or placebo throat spray. The clinical symptoms of the patients were compared between the two groups at baseline and then at 24 hours, 48 hours, 5 days and 10 days after the starting the treatment procedure. Results: As per results, the quality of honey sample was met to the standard honey criteria. The treatment and placebo groups were statistically similar in terms of demographic specifications or clinical symptoms at the time to enter the study. Pharyngitis recovery was better in treatment group than in the placebo group; this positive effect was statistically significant for symptoms of morning phlegm and painful swallowing, 24 hours after the starting treatment. In treatment group, after 48 hours, symptoms of fever and painful swallowing were resolved, while this indicator was 23% in placebo group. Also, throat pain of 85.71% of patients in treatment group and 17.14% of patients in placebo group was relieved. Overall, the mean recovery time in treatment group was shorter than placebo group. Conclusion: The findings of this study showed that the use of honey throat spray as auxiliary treatment of pharyngitis can improve the clinical symptoms of pharyngitis and reduce recovery time.
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蜂蜜咽喉喷雾剂辅助治疗咽炎的临床评价
背景与目的:由于细菌耐药性的日益普遍,咽炎辅助治疗的应用越来越受到重视。本研究的目的是探讨蜂蜜咽喉喷雾剂在辅助治疗诊断为咽炎的患者中的作用。方法:首先对蜂蜜样品的不同理化质量参数进行评价。然后,准备好蜂蜜瓶和安慰剂咽喷雾剂。一项一步双盲研究纳入了70名诊断为咽炎的患者。除了标准治疗外,每位患者还接受蜂蜜或安慰剂咽喉喷雾中的一种。比较两组患者在基线时以及开始治疗程序后24小时、48小时、5天和10天的临床症状。结果:蜂蜜样品质量符合蜂蜜标准。在进入研究时,治疗组和安慰剂组在人口统计学指标或临床症状方面具有统计学相似性。治疗组的咽炎恢复情况优于安慰剂组;在开始治疗后24小时,这种积极作用对晨吐痰和吞咽疼痛的症状具有统计学意义。在治疗组中,48小时后,发烧和吞咽疼痛的症状得到缓解,而安慰剂组的这一指标为23%。此外,治疗组85.71%的患者和安慰剂组17.14%的患者的喉咙痛得到缓解。总体而言,治疗组的平均恢复时间短于安慰剂组。结论:本研究结果表明,蜂蜜咽喉喷雾剂辅助治疗咽炎可改善咽炎的临床症状,缩短恢复时间。
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