Glia-to-Neuron Conversion Alleviates Symptoms of Neurological Disease in Mice

Abstract

A recent study published in Cell revealed that gliato-neuron conversion alleviates symptoms of two top-ranked neurological diseases in mice. This work was performed by researchers from Dr. YANG Hui’s Lab at the Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience (ION), State Key Laboratory of Neuroscience, Chinese Academy of Sciences. This study showed that knockdown of a single gene Ptbp1 using a recently developed RNA-targeting CRISPR system CasRx, resulted in the conversion of Müller glia (MG) into retinal ganglion cells (RGCs) Glia-to-Neuron Conversion Alleviates Symptoms of Neurological Disease in Mice