THERPA v2: an update of a small molecule database related to prion protein regulation and prion disease progression

Abstract

Prion diseases are rare, rapidly progressive neurodegenerative disorders that affect mammalian species [1,2]. Abnormal accumulation of infectious form of the prion protein in the brain causes prion disease. Various small molecules have been used to inhibit and treat this disease [3,4]. We built a repository of therapeutic molecules associated with prion protein and prion diseases (THERPA) to allow users to easily browse information describing various small molecules in publicly available articles [5]. THERPA is an open-access database containing data regarding small molecules related to prion protein and prion diseases, which is aimed at allowing researchers to easily explore and analyse data of interest. Here, we describe the relocation of the webpage and THERPA database updates. The THERPA repository has been relocated to the Korea National Institute of Health website for stable maintenance (www.nih.go.kr/ therpa). The e-Government Standard Framework (www.egovframe.go.kr) was used to create the