A Nutrigenetic Approach to Investigate ApoB EcoR1 Polymorphism–Dietary Acid Load Interactions on Lipid and Anthropometric-Related Outcomes in Adults with Dyslipidemic Type 2 Diabetes

IF 2 4区 医学 Q3 GENETICS & HEREDITY Lifestyle Genomics Pub Date : 2022-12-14 DOI:10.1159/000528656
Zeinab Naeini, Faezeh Abaj, Z. Esmaeily, E. Alvandi, Masoumeh Rafiee, F. Koohdani
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引用次数: 1

Abstract

Introduction: Despite multiple studies which have considered the role of dietary acid load (DAL) or Apolipoprotein B (ApoB) EcoR1 polymorphism in diabetes, none have assessed their interplay effect on metabolic markers. Therefore, this study aimed to determine the interaction of EcoR1 and DAL on metabolic markers among adults with Type 2 diabetes mellitus (T2DM). Methods: 492 randomly selected individuals with T2DM were recruited for this cross-sectional study. Dietary intake was evaluated by a validated food frequency questionnaire. DAL was assessed as net-endogenous acid production (NEAP) and potential renal acid load (PRAL). Real-time-PCR was used to genotype EcoR1. Metabolic markers were also assessed. The interaction effect of the polymorphism and DAL indexes was analyzed by analysis of covariance (ANCOVA). Result: The frequency of EcoR1 genotypes was not different between dyslipidemic and normolipidemic participants (P>0.05). Among participants with dyslipidemia, those with the GG genotype and who consumed a higher level of NEAP had higher body mass index (BMI) (p=0.03) and waist circumference (WC; p =0.02). Moreover, triglyceride (TG) concentration (P=0.007), the LDL/HDL ratio (P=0.03) and the TG/HDL (P=0.03) ratio were significantly higher in A allele carriers with higher than the median intake of NEAP, in comparison with GG homozygotes. Finally, GA/AA carriers who had a higher intake of PRAL had a higher TG concentration (P=0.006) and TG/HDL ratio (P=0.01) compared to lower median intake in the dyslipidemia group. Discussion/Conclusion: In the dyslipidemic group, there was a higher TG concentration among individuals with the GA/AA genotype and a higher intake of NEAP/ PRAL. Also, in this group, a higher intake of NEAP may be considered as a risk factor for increased levels of BMI and WC among participants with the GG genotype.
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研究ApoB-EcoR1多态性的营养遗传学方法——饮食酸负荷相互作用对2型糖尿病成人血脂异常和人体测量相关结果的影响
引言:尽管多项研究考虑了饮食酸负荷(DAL)或载脂蛋白B(ApoB)EcoR1多态性在糖尿病中的作用,但没有一项研究评估它们对代谢标志物的相互作用。因此,本研究旨在确定EcoR1和DAL对成人2型糖尿病(T2DM)代谢标志物的相互作用。方法:随机选择492名T2DM患者进行横断面研究。饮食摄入量通过一份经过验证的食物频率问卷进行评估。DAL评估为内源性净产酸量(NEAP)和潜在肾脏酸负荷(PRAL)。采用实时PCR技术对EcoR1进行基因分型。还评估了代谢标志物。通过协方差分析(ANCOVA)分析多态性与DAL指标的交互作用。结果:血脂异常和血脂正常参与者的EcoR1基因型频率没有差异(P>0.05)。在血脂异常参与者中,GG基因型和NEAP水平较高的参与者具有较高的体重指数(BMI)(P=0.03)和腰围(WC;P=0.02)。此外,甘油三酯(TG)浓度(P=0.007),NEAP摄入量高于中位数的A等位基因携带者的LDL/HDL比率(P=0.03)和TG/HDL比率(P=0.003)显著高于GG纯合子。最后,与血脂异常组的中位摄入量较低相比,PRAL摄入量较高的GA/AA携带者具有较高的TG浓度(P=0.006)和TG/HDL比率(P=0.01)。讨论/结论:在血脂异常组中,GA/AA基因型个体的TG浓度较高,NEAP/PRAL摄入量较高。此外,在这一组中,较高的NEAP摄入量可能被认为是GG基因型参与者BMI和WC水平升高的风险因素。
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来源期刊
Lifestyle Genomics
Lifestyle Genomics Agricultural and Biological Sciences-Food Science
CiteScore
4.00
自引率
7.70%
发文量
11
审稿时长
28 weeks
期刊介绍: Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.
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