Synthesis and characterization of poly(N-isopropylmethacrylamide-co-N-isopropylacrylamide) copolymers

IF 0.8 4区 工程技术 Q4 ENGINEERING, CHEMICAL Hemijska Industrija Pub Date : 2020-05-01 DOI:10.2298/hemind190717007u
M. Urošević, Ljubiša Nikolić, S. Ilić-Stojanović, Aleksandar Zdravković, V. Nikolić
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引用次数: 3

Abstract

Copolymeric hydrogels of poly(N-isopropylmethacrylamide-co-N-isopropylacrylamide), p(NIPMAM/NIPAM), are synthesized by radical polymerization of N-isopropylmethacryl­amide (NIPMAM) and N-isopropylacrylamide (NIPAM) monomers by using the cross-linker ethylen glycol dimethacrylate (EGDM). The synthesized copolymeric p(NIPMAM/NIPAM) hydrogels, starting monomers and the cross-linker were structurally characterized by using Fourier transform infrared spectroscopy (FTIR). The amounts of residual reactants in the synthesized hydrogels were determined by high-pressure liquid chromatography (HPLC). Swelling of p(NIPMAM/NIPAM) hydrogels was investigated in relation to the temperature and pH value of the solution. The obtained values of residual monomer quantities are within acceptable limits and in the range from 2.69 to 5.25 mg g -1 for NIPMAM and 14.55 to 30.80 mg g -1 for NIPAM. The synthesized p(NIPMAM/NIPAM) hydrogels are negatively thermosensitive. The most common mechanisms of transport of a swelling solution in p(NIPMAM/NIPAM) hydrogels are polymer chain relaxation, (Case III), and the anomalous type of diffusion (non-Fickian diffusion). The maximal equilibrium swelling degree of 51.19 was reached by the p(NIPMAM/NIPAM) hydrogel with 1.5 mol% of EGDM at the temperature of 25 o C and pH 4, whereas the lowest one of 0.98 was exhibited by the hydrogel with 3 mol% of EGDM at the temperature of 80 o C and pH 7. Due to their low content of residual reactants and a satisfactory degree of swelling at various pH values, synthesized p(NIPMAM/NIPAM) hydrogels can be applied as carriers for the controlled release of pharmaceutically active substances.
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聚n -异丙基甲基丙烯酰胺-co- n -异丙基丙烯酰胺共聚物的合成与表征
以交联剂二甲丙烯酸乙二醇酯(EGDM)为原料,将n -异丙基甲基丙烯酰胺(NIPMAM)与n -异丙基丙烯酰胺(NIPAM)单体自由基聚合,合成了聚(n -异丙基甲基丙烯酰胺-co- n -异丙基丙烯酰胺)共聚水凝胶p(NIPMAM/NIPAM)。利用傅里叶红外光谱(FTIR)对合成的共聚物p(NIPAM /NIPAM)水凝胶、起始单体和交联剂进行了结构表征。采用高压液相色谱法测定合成水凝胶中残留反应物的含量。研究了p(NIPAM /NIPAM)水凝胶的溶胀与溶液温度和pH值的关系。所得的残留单体量值在可接受的范围内,NIPAM的范围为2.69至5.25 mg g -1, NIPAM的范围为14.55至30.80 mg g -1。合成的p(NIPAM /NIPAM)水凝胶具有负热敏性。p(NIPAM /NIPAM)水凝胶中溶胀溶液最常见的输运机制是聚合物链弛豫(案例III)和异常扩散(非菲克扩散)。当温度为25℃,pH为4时,加入1.5 mol% EGDM的p(NIPAM /NIPAM)水凝胶的平衡溶胀度最大,为51.19;当温度为80℃,pH为7时,加入3 mol% EGDM的水凝胶的平衡溶胀度最小,为0.98。合成的p(NIPAM /NIPAM)水凝胶由于其残留反应物含量低,在各种pH值下都有令人满意的溶胀程度,可以作为药物活性物质控释的载体。
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来源期刊
Hemijska Industrija
Hemijska Industrija 工程技术-工程:化工
CiteScore
1.60
自引率
11.10%
发文量
12
审稿时长
6-12 weeks
期刊介绍: The Journal Hemijska industrija (abbreviation Hem. Ind.) is publishing papers in the field of Chemical Engineering (Transport phenomena; Process Modeling, Simulation and Optimization; Thermodynamics; Separation Processes; Reactor Engineering; Electrochemical Engineering; Petrochemical Engineering), Biochemical Engineering (Bioreactors; Protein Engineering; Kinetics of Bioprocesses), Engineering of Materials (Polymers; Metal materials; Non-metal materials; Biomaterials), Environmental Engineeringand Applied Chemistry. The journal is published bimonthly by the Association of Chemical Engineers of Serbia (a member of EFCE - European Federation of Chemical Engineering). In addition to professional articles of importance to industry, scientific research papers are published, not only from our country but from all over the world. It also contains topics such as business news, science and technology news, information on new apparatus and equipment, and articles on environmental protection.
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