{"title":"Three-dimensional (3D) printing of oral dental films (ODFs) using blended Compactcel® polymers through semi-solid extrusion (SSE) bioprinter","authors":"Rohit Bhawale, Purushottam Suryavanshi , Subham Banerjee","doi":"10.1016/j.bprint.2023.e00287","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>This study aimed to prototype oral dental films (ODFs) loaded with diclofenac sodium<span><span><span> (DS) using two different grades of CompactCel® polymers through a semi-solid extrusion (SSE) bioprinter. This three-dimensional (3D) printed ODFs were developed for the treatment of </span>toothaches with immediate and </span>sustained release<span><span> features. Two different grades of CompactCel® polymers, CompactCel® P 002.02 SR and CompactCel® P Clear 194.04 SIL, with sustained and immediate release features, respectively, were explored in this study. A blend of CompactCel® polymers was found to be capable of forming hydrogels with the addition of </span>dibutyl phthalate (DBP) as a </span></span></span>plasticizer to improve the foldability/flexibility of the developed ODFs. ODFs were 3D printed using an SSE bioprinter by varying the amount of DBP. All 3D bio-printed ODFs were analyzed systematically in terms of </span><em>in vitro</em><span> physicochemical characteristics, including drug<span> content, drug release, and release kinetics models. The </span></span><em>in vitro</em><span> release graph of DS from ODFs showed an initial burst release of around 50–70% in 20 min followed by the sustained release of up to 150 min for all the formulations. The prototype ODFs showed dual drug delivery features in terms of initial fast release followed by sustained release. Thus, these ideal biomaterial combinations were explored for the first time to establish not only their pharmaceutical 3D bioprinting<span> capabilities but also their potential for drug delivery applications.</span></span></p></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioprinting","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405886623000301","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Computer Science","Score":null,"Total":0}
引用次数: 2
Abstract
This study aimed to prototype oral dental films (ODFs) loaded with diclofenac sodium (DS) using two different grades of CompactCel® polymers through a semi-solid extrusion (SSE) bioprinter. This three-dimensional (3D) printed ODFs were developed for the treatment of toothaches with immediate and sustained release features. Two different grades of CompactCel® polymers, CompactCel® P 002.02 SR and CompactCel® P Clear 194.04 SIL, with sustained and immediate release features, respectively, were explored in this study. A blend of CompactCel® polymers was found to be capable of forming hydrogels with the addition of dibutyl phthalate (DBP) as a plasticizer to improve the foldability/flexibility of the developed ODFs. ODFs were 3D printed using an SSE bioprinter by varying the amount of DBP. All 3D bio-printed ODFs were analyzed systematically in terms of in vitro physicochemical characteristics, including drug content, drug release, and release kinetics models. The in vitro release graph of DS from ODFs showed an initial burst release of around 50–70% in 20 min followed by the sustained release of up to 150 min for all the formulations. The prototype ODFs showed dual drug delivery features in terms of initial fast release followed by sustained release. Thus, these ideal biomaterial combinations were explored for the first time to establish not only their pharmaceutical 3D bioprinting capabilities but also their potential for drug delivery applications.
期刊介绍:
Bioprinting is a broad-spectrum, multidisciplinary journal that covers all aspects of 3D fabrication technology involving biological tissues, organs and cells for medical and biotechnology applications. Topics covered include nanomaterials, biomaterials, scaffolds, 3D printing technology, imaging and CAD/CAM software and hardware, post-printing bioreactor maturation, cell and biological factor patterning, biofabrication, tissue engineering and other applications of 3D bioprinting technology. Bioprinting publishes research reports describing novel results with high clinical significance in all areas of 3D bioprinting research. Bioprinting issues contain a wide variety of review and analysis articles covering topics relevant to 3D bioprinting ranging from basic biological, material and technical advances to pre-clinical and clinical applications of 3D bioprinting.