Immunology of Endometriosis; a Systematic Review

Abstract

Copyright© 2019, ASP Ins. This open-access article is published under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License which permits Share (copy and redistribute the material in any medium or format) and Adapt (remix, transform, and build upon the material) under the Attribution-NonCommercial terms. [1] Immunology of endometriosis [2] Natural killer cells: Key players in endometriosis [3] Enhancement of human monocyte and peritoneal macrophage chemiluminescence activities in women with endometriosis [4] Spontaneous and induced synthesis of cytokines by peripheral blood monocytes in patients with endometriosis [5] Peritoneal fluid-mediated enhancement of eutopic and ectopic endometrial cell proliferation is dependent on tumor necrosis factor-alpha in women with endometriosis [6] Immunological aspects of endometriosis [7] Atherosclerosis, oxidation and endometriosis [8] The development of cytotoxicity in peritoneal macrophages from women with endometriosis [9] Modulation of neutrophil apoptosis by plasma and peritoneal fluid from patients with advanced endometriosis [10] Dendritic cell populations in the eutopic and ectopic endometrium of women with endometriosis [11] Immunobiology of endometriosis [12] Targeting mast cells in endometriosis with janus kinase 3 inhibitor, JANEX-1 [13] Clinical immunological aspects of genital endometriosis [14] The effect of estradiol on the production and secretion of complement component 3 by the rat uterus and surgically induced endometriotic tissue [15] Is endometriosis an autoimmune disease? [16] Autoimmunity in infertile patients with endometriosis [17] Endometriosis: can it produce an autoimmune response resulting in infertility? [18] Autoimmunity to endometrium and ovary in endometriosis [19] Autoimmunity in endometriosis: Relevance to infertility [20] Is adenomyosis an immune disease? [21] The effect of endometriosis, its stage and activity, and of autoantibodies on in vitro fertilization and embryo transfer success rates [22] Treating endometriosis as an autoimmune disease [23] Deficient cellular immunity in endometriosis [24] Immunological aspects of endometriosis: A review [25] T regulatory lymphocytes in patients with endometriosis [26] Interleukin-17 and type 17 helper T cells [27] Th17 cells in human disease [28] Recruitment of CCR6-expressing Th17 cells by CCL 20 secreted from IL-1 beta-, TNF-alpha-, and IL-17A-stimulated endometriotic stromal cells [29] Immunological aspects of endometriosis : an update Background Endometriosis is a common and gynecologic illness affecting women in reproductive age and characterized by the growth of endometrial-like tissue and stroma outside the uterine cavity. It is also a significant cause of infertility. The cause of endometeriosis is still unclear but an increasing number of studies have been investigated the role of immune system in its etiology and pathogenesis. So, it is well known that endometriosis is an inflammatory disease and has dysfunction in patient’s immune response. The development of endometriosis may be influenced by immune factors including formation of autoantibodies, impaired immune recognition and clearance of ectopic endometrial cells. In this review, we will summarize the current knowledge about immunological factors in women with endometriosis that provide the basis for developing new approaches to patient management. In this review, the basic contents were obtained from textbooks and new surveies were searched from pubmed, science direct and google scholar in the period of 1980-2015. Conclusion Immunological factors have been considered as important factors in the prevention and treatment of endometriosis. In addition, clinical studies are recommended to understanding the mechanism and the role of immunological factors in the prevention and treatment of endometriosis. A B S T R A C T A R T I C L E I N F O