Comparison of 3D conformal and intensity modulated radiotherapy in early stage oral tongue cancer: dosimetric and radiobiological evaluation

Q4 Health Professions Iranian Journal of Radiation Research Pub Date : 2020-01-10 DOI:10.18869/ACADPUB.IJRR.18.1.33
A. Shanei, I. Abedi, Pegah Saadatmand, A. Amouheidari, Hadi Akbari-Zadeh
{"title":"Comparison of 3D conformal and intensity modulated radiotherapy in early stage oral tongue cancer: dosimetric and radiobiological evaluation","authors":"A. Shanei, I. Abedi, Pegah Saadatmand, A. Amouheidari, Hadi Akbari-Zadeh","doi":"10.18869/ACADPUB.IJRR.18.1.33","DOIUrl":null,"url":null,"abstract":"Background: The aim of this study was to compare the dosimetric and radiobiological efficiency of various intensity modulated radiotherapy (IMRT) techniques with 3D conventional radiotherapy (3D-CRT) technique in the treatment of early stage oral tongue cancer. Materials and Methods: This study was performed on 38 CT images of patients who were planned with 3DCRT and three sets of IMRT treatment plans including five, seven and nine fields with prescribed dose of 66 Gy to planning target volume. The dose volume histograms, homogeneity index (HI), conformity index (CI) and normal tissue complication probability (NTCP) of main organs at risk were derived using Prowess Panther treatment planning system. Results: The results of this study indicated an increase in HI and CI for IMRT plans compared to 3D-CRT. Furthermore, IMRT techniques led to a statistically significant reduction in received dose by mandible (up to 10.10 Gy) and thyroid (up to 13.59 Gy) compared to the conventional technique used; whereas, it led to a statistically significant increase in received dose by parotid glands (up to 7.62 Gy) and brain stem (up to 9.87 Gy). In addition, IMRT increased (up to 12.79%) the probability of occurrence of parotid xerostomia and decreased mandibular complications (up to 7.76%) in comparison to conventional treatment. Conclusions: It can be concluded that IMRT can be more successful in improving oral tongue cancer treatment with more conformity and homogeneity. However, IMRT may not be required for all patients with oral tongue cancer at early stage of the disease.","PeriodicalId":14498,"journal":{"name":"Iranian Journal of Radiation Research","volume":"18 1","pages":"33-42"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Radiation Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18869/ACADPUB.IJRR.18.1.33","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Health Professions","Score":null,"Total":0}
引用次数: 3

Abstract

Background: The aim of this study was to compare the dosimetric and radiobiological efficiency of various intensity modulated radiotherapy (IMRT) techniques with 3D conventional radiotherapy (3D-CRT) technique in the treatment of early stage oral tongue cancer. Materials and Methods: This study was performed on 38 CT images of patients who were planned with 3DCRT and three sets of IMRT treatment plans including five, seven and nine fields with prescribed dose of 66 Gy to planning target volume. The dose volume histograms, homogeneity index (HI), conformity index (CI) and normal tissue complication probability (NTCP) of main organs at risk were derived using Prowess Panther treatment planning system. Results: The results of this study indicated an increase in HI and CI for IMRT plans compared to 3D-CRT. Furthermore, IMRT techniques led to a statistically significant reduction in received dose by mandible (up to 10.10 Gy) and thyroid (up to 13.59 Gy) compared to the conventional technique used; whereas, it led to a statistically significant increase in received dose by parotid glands (up to 7.62 Gy) and brain stem (up to 9.87 Gy). In addition, IMRT increased (up to 12.79%) the probability of occurrence of parotid xerostomia and decreased mandibular complications (up to 7.76%) in comparison to conventional treatment. Conclusions: It can be concluded that IMRT can be more successful in improving oral tongue cancer treatment with more conformity and homogeneity. However, IMRT may not be required for all patients with oral tongue cancer at early stage of the disease.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
三维适形放疗与调强放疗治疗早期口腔舌癌症的比较:剂量测定与放射生物学评价
背景:本研究旨在比较不同调强放疗(IMRT)技术与三维常规放疗(3D-CRT)技术治疗早期口腔舌癌的剂量测定和放射生物学效率。材料和方法:本研究对38例患者的CT图像进行了研究,这些患者计划使用3DCRT和三套IMRT治疗计划,包括5、7和9个场,处方剂量为66Gy,以计划目标体积。使用Prowess Panther治疗计划系统导出主要危险器官的剂量-体积直方图、同质性指数(HI)、一致性指数(CI)和正常组织并发症概率(NTCP)。结果:本研究结果表明,与3D-CRT相比,IMRT计划的HI和CI有所增加。此外,与使用的传统技术相比,IMRT技术导致下颌骨(高达10.10Gy)和甲状腺(高达13.59Gy)的接受剂量在统计学上显著减少;而它导致腮腺(高达7.62Gy)和脑干(高达9.87Gy)的接受剂量在统计学上显著增加。此外,与传统治疗相比,IMRT增加了(高达12.79%)腮腺口干症的发生概率,并减少了下颌并发症(高达7.76%)。结论:IMRT在改善口腔舌癌症治疗方面具有更大的一致性和同质性。然而,并非所有处于疾病早期的口腔舌癌症患者都需要IMRT。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Iranian Journal of Radiation Research
Iranian Journal of Radiation Research RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
0.67
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Iranian Journal of Radiation Research (IJRR) publishes original scientific research and clinical investigations related to radiation oncology, radiation biology, and Medical and health physics. The clinical studies submitted for publication include experimental studies of combined modality treatment, especially chemoradiotherapy approaches, and relevant innovations in hyperthermia, brachytherapy, high LET irradiation, nuclear medicine, dosimetry, tumor imaging, radiation treatment planning, radiosensitizers, and radioprotectors. All manuscripts must pass stringent peer-review and only papers that are rated of high scientific quality are accepted.
期刊最新文献
How to deal with the relationship between hypoxia and radiotherapy in the hypofractionated radiotherapy era Chemoradiotherapy alone or in combination with Endostar for patients with advanced non-small cell lung cancer: A systematic review and meta-analysis Measurement of exposure to radionuclides (40-K, 226-Ra, and 232-Th) in the oil and gas drilling industry Effects of particle size and weight percentage of heavy metal elements on photon shielding efficiency of reinforced polymer composites Dosimetric evaluation of field-in-field and sliding-window IMRT in endometrium cancer patients with a new approach for the conformity index
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1