{"title":"Advances in novel vaccine adjuvants based on TLR4 agonists","authors":"Qiao Li, Yuepeng Wang, Yusen Zhou, Z. Kou","doi":"10.3760/CMA.J.ISSN.0254-5101.2019.08.013","DOIUrl":null,"url":null,"abstract":"Toll-like receptor 4 (TLR4), a type Ⅰ transmembrane protein, has been extensively studied in the Toll-like receptor family at present. TLR4 ligands include lipopolysaccharides (LPS) present in the outer membrane of gram-negative bacteria and monophosphoryl lipid A (MPLA) which is a derivative of LPS. TLR4 agonists, alone, as a major component of compound adjuvants or in combination with other TLRs agonists, have been widely used as adjuvants in various vaccines and demonstrated great potential in vaccine development. This review addressed the discovery, application, features and prospect of novel vaccine adjuvants based on TLR4 agonists, aiming to provide reference for rational use of adjuvants and further development. \n \n \nKey words: \nAdjuvant; Immunostimulant; TLR4; Vaccine","PeriodicalId":10089,"journal":{"name":"中华微生物学和免疫学杂志","volume":"39 1","pages":"638-644"},"PeriodicalIF":0.0000,"publicationDate":"2019-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华微生物学和免疫学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.0254-5101.2019.08.013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Immunology and Microbiology","Score":null,"Total":0}
引用次数: 1
Abstract
Toll-like receptor 4 (TLR4), a type Ⅰ transmembrane protein, has been extensively studied in the Toll-like receptor family at present. TLR4 ligands include lipopolysaccharides (LPS) present in the outer membrane of gram-negative bacteria and monophosphoryl lipid A (MPLA) which is a derivative of LPS. TLR4 agonists, alone, as a major component of compound adjuvants or in combination with other TLRs agonists, have been widely used as adjuvants in various vaccines and demonstrated great potential in vaccine development. This review addressed the discovery, application, features and prospect of novel vaccine adjuvants based on TLR4 agonists, aiming to provide reference for rational use of adjuvants and further development.
Key words:
Adjuvant; Immunostimulant; TLR4; Vaccine
期刊介绍：
Chinese Journal of Microbiology and Immunology established in 1981. It is one of the series of journal sponsored by Chinese Medical Association. The aim of this journal is to spread and exchange the scientific achievements and practical experience in order to promote the development of medical microbiology and immunology. Its main contents comprise academic thesis, brief reports, reviews, summaries, news of meetings, book reviews and trends of home and abroad in this field. The distinguishing feature of the journal is to give the priority to the reports on the research of basic theory, and take account of the reports on clinical and practical skills.
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