Evaluation of in vivo wound healing and anti-inflammatory activity of crude extract of the fruits of Brucea antidysentrica in mice

Q1 Medicine Wound Medicine Pub Date : 2018-06-01 DOI:10.1016/j.wndm.2018.05.005

Zenaw Tessema , Eyasu Makonnen , Asfaw Debella , Yalew Molla

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引用次数: 8

Abstract

Background

Brucea antidysentrica is traditionally used to treat various conditions. Though, fruits of B. antidysentrica are claimed to promote wound healing; there is no scientific evidence that supports the traditional claim. Therefore, this study was aimed to evaluate the wound healing and anti-inflammatory activities of the extract.

Methods

Extracts were formulated as 1% and 2% ointments. Simple and nitrofurazone (0.2%) ointments were used as controls for the wound healing. A dose of 100, 200 and 400 mg/kg body weight were used for anti-inflammatory activity tests using vehicle and indomethacin 10 mg/kg as controls. Wound contraction rate, complete epithelialization period, skin breaking strength and edema inhibition were evaluated.

Results

On last day of treatment, fruits extract showed a significant wound healing activity at strengths of 2% compared with negative control as. On the same day 1% MFE was found to increase the % wound contraction significantly (P < 0.01). Only 2% MFE resulted in a significant increase in tensile strength (p < 0.01). The 200 and 400 mg/kg doses were revealed a significant anti-inflammatory effect particularly at 3 and 4 h.

Conclusion

The extract supports traditional claims for wound healing and anti-inflammatory activity.

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布氏果粗提物对小鼠体内创面愈合及抗炎作用的评价

背景:抗痢疾布鲁氏菌传统上用于治疗各种疾病。虽然，抗痢疾杆菌的果实被声称能促进伤口愈合;没有科学证据支持这种传统的说法。因此，本研究旨在评价其伤口愈合和抗炎活性。方法分别配制1%和2%软膏。单纯和硝基呋喃酮(0.2%)软膏作为对照，用于伤口愈合。用100、200和400 mg/kg体重的剂量进行抗炎活性试验，对照物和吲哚美辛10 mg/kg。观察创面收缩率、完全上皮化时间、破皮强度和水肿抑制程度。结果在治疗的最后一天，与阴性对照相比，果提取物在2%的强度下具有显著的伤口愈合活性。同日，1% MFE显著提高创面收缩率(P < 0.01)。只有2%的MFE导致抗拉强度显著增加(p < 0.01)。200和400 mg/kg剂量显示出显著的抗炎作用，特别是在3和4 h时。结论该提取物支持传统的伤口愈合和抗炎活性的说法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wound Medicine Medicine-Surgery

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