Ossifying fibromyxoid tumour with an unusually prominent central ossification harbouring EPC1-PHF1 gene fusion: A case report and literature review

IF 0.4 Q3 MEDICINE, GENERAL & INTERNAL Proceedings of Singapore Healthcare Pub Date : 2022-06-01 DOI:10.1177/20101058221129722
Tzy Harn Chua, S. Lai, K. Sittampalam
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Abstract

Ossifying fibromyxoid tumour (OFMT) is a soft tissue neoplasm of uncertain differentiation, with potential for recurrences and metastases depending on the presence of atypical or malignant histological features. Most cases show an incomplete shell of mature bone in the periphery of the lesion. Recurrent PHF1 gene rearrangements were also recently reported in OFMTs, with the most common rearrangement involving a fusion to EP400. We report a case of a 75-year-old male that was diagnosed with an OFMT showing an unusually prominent central ossification. Further, this lesion also harboured the less commonly reported EPC1-PHF1 gene fusion, thus further characterising the morphological features that are associated with this molecular event in this entity. Differential diagnoses of lesions with prominent ossification and emerging molecular findings associated with this entity are discussed.
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骨化性纤维黏液样肿瘤伴有异常突出的中心骨化,包含EPC1-PHF1基因融合:1例报告和文献复习
骨化性纤维黏液样瘤(OFMT)是一种不确定分化的软组织肿瘤,具有复发和转移的可能性,取决于非典型或恶性组织学特征的存在。大多数病例显示病变周围有成熟骨的不完整外壳。最近在OFMTs中也报道了复发性PHF1基因重排,最常见的重排涉及与EP400的融合。我们报告一个75岁的男性病例,被诊断为OFMT,显示异常突出的中央骨化。此外,该病变还包含较少报道的EPC1-PHF1基因融合,从而进一步表征了该实体中与该分子事件相关的形态学特征。鉴别诊断病变与突出骨化和新兴的分子发现与这个实体讨论。
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来源期刊
Proceedings of Singapore Healthcare
Proceedings of Singapore Healthcare MEDICINE, GENERAL & INTERNAL-
CiteScore
0.90
自引率
0.00%
发文量
42
审稿时长
15 weeks
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