Can glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors help in mitigating the risk of atrial fibrillation in patients with diabetes?

IF 1.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiovascular Endocrinology & Metabolism Pub Date : 2022-06-08 DOI:10.1097/XCE.0000000000000265
S. Thotamgari, U. Grewal, A. Sheth, Akhilesh Babbili, Paari Dominic
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引用次数: 3

Abstract

The role of glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase-4 inhibitors (DPP-4i) in mitigating the risk of atrial fibrillation (AF) remains unknown. We interrogated the Food and Drug Administration’s Adverse Event Reporting System (FAERS) database to study the association between AF-related adverse events and the use of GLP-1 RA and DPP-4i. A signal of disproportionate reporting of AF was detected with the DPP-4i group compared with all the other drugs in the FAERS database [ROR, 2.56; 95% confidence interval (CI), 2.10–3.12], whereas there was no disproportionality signal detected with the GLP-1 RA group (ROR, 0.90; 95% CI, 0.78–1.03) although liraglutide showed a significant disproportionality signal (ROR, 2.51; 95% CI, 2.00–3.15). Our analysis supports the existing body of literature demonstrating the cardiac safety of GLP-1 RA but raises concerns about the apparent increase in the risk of AF associated with DPP-4i. Further clinical and translational studies are needed to validate these findings.
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胰高血糖素样肽-1受体激动剂和二肽基肽酶-4抑制剂是否有助于减轻糖尿病患者房颤的风险?
胰高血糖素样肽-1受体激动剂(GLP-1 RA)和二肽基肽酶-4抑制剂(DPP-4i)在降低心房颤动(AF)风险方面的作用尚不清楚。我们询问了美国食品药品监督管理局的不良事件报告系统(FAERS)数据库,以研究房颤相关不良事件与GLP-1 RA和DPP-4i的使用之间的关系。与FAERS数据库中的所有其他药物相比,DPP-4i组检测到房颤报告不成比例的信号[ROR,2.56;95%置信区间(CI),2.10–3.12],尽管利拉鲁肽显示出明显的不均衡信号(ROR,2.51;95%CI,2.00–3.15),但GLP-1 RA组未检测到不均衡信号DPP-4i。需要进一步的临床和转化研究来验证这些发现。
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来源期刊
Cardiovascular Endocrinology & Metabolism
Cardiovascular Endocrinology & Metabolism CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
5.60
自引率
0.00%
发文量
24
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