Antiemetic effects of metoclopramide with and without dexamethasone in children with minor head trauma: a single blind randomized clinical trial

Electronic Physician Pub Date : 2018-11-25 DOI:10.19082/7307
Meisam Moezzi, Ali Delirrooyfard, H. Motamed, M. Mortazavi
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引用次数: 3

Abstract

Background: Trauma in the head is one of the most common childhood injuries. Children with minor head trauma are at higher risk of intracranial injury (ICI). Vomiting is one of the most common signs after minor head trauma in children, and different treatments are suggested for managing it. Objective: To determine the antiemetic effects of dexamethasone in children with minor head trauma. Methods: This single blind randomized clinical trial study was carried out during the period from September 2015 to August 2016 in Imam Khomeini and Golestan Hospitals in Ahvaz, Iran, on 64 children (2-8 years old) with minor head trauma (Minor head trauma was considered as GCS 14-15) who were admitted to the hospitals’ emergency departments. In the intervention group, metoclopramide (0.15 mg/kg) and dexamethasone (0.15 mg/kg) were injected. In the placebo group, patients received metoclopramide (0.15 mg/kg) and placebo. Nausea severity was measured using Rhodes Index of Nausea and Vomiting. The data were analyzed using SPSS version 19. We used descriptive statistics, Chi-squared, t-test, and ANOVA for the analyses of the data. P-value of less than 0.05 was defined as the level of significance. Results: Finally, 62 patients (mean age of 56.4 and 62% male gender) attended the study and were equally divided into intervention and placebo groups. The Rhodes Index of Nausea and Vomiting on the intervention and placebo groups was 4.9±3.73 and 7.19±3.79, respectively (p=0.021). Conclusion: Collectively, our results indicated that dexamethasone can be used as an effective medication along with metoclopramide to control vomiting in children with minor head trauma. Trial registration: The trial was registered at the Iranian Registry of Clinical Trials (http://www.irct.ir) with the Irct ID: IRCT2016081128944N1. Funding: The authors received no financial support for the research, authorship, and/or publication of this article.
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甲氧氯普胺加和不加地塞米松对轻度头部创伤儿童的止吐效果:一项单盲随机临床试验
背景:头部创伤是儿童最常见的损伤之一。轻微头部创伤的儿童发生颅内损伤(ICI)的风险更高。呕吐是儿童轻微头部创伤后最常见的症状之一,建议采取不同的治疗方法。目的:观察地塞米松对儿童轻微头部损伤的止吐作用。方法:这项单盲随机临床试验研究于2015年9月至2016年8月在伊朗阿瓦兹的伊玛目霍梅尼和戈勒斯坦医院进行,研究对象为64名(2-8岁)入住医院急诊科的轻度头部创伤(轻度头部创伤被认为为GCS 14-15)儿童。干预组注射甲氧氯普胺0.15mg/kg和地塞米松0.15mg/kg。在安慰剂组中,患者接受甲氧氯普胺(0.15 mg/kg)和安慰剂治疗。使用罗兹恶心呕吐指数测量恶心的严重程度。使用SPSS 19版对数据进行分析。我们使用描述性统计学、卡方检验、t检验和方差分析对数据进行分析。P值小于0.05被定义为显著性水平。结果:最后,62名患者(平均年龄56.4岁,62%为男性)参加了研究,并被平均分为干预组和安慰剂组。干预组和安慰剂组的恶心和呕吐罗兹指数分别为4.9±3.73和7.19±3.79(p=0.021)。试验注册:该试验在伊朗临床试验注册处注册(http://www.irct.ir)Irct ID:IRCT2016081128944N1。资助:作者在研究、撰写和/或发表这篇文章方面没有得到任何资助。
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