H. Schaible, A. Ebersberger, G. Natura, E. Vazquez
{"title":"The role of neuroimmune interactions in musculoskeletal pain","authors":"H. Schaible, A. Ebersberger, G. Natura, E. Vazquez","doi":"10.1515/nf-2022-0001","DOIUrl":null,"url":null,"abstract":"Abstract Interactions of the immune system and the nociceptive system play an important role in the generation and maintenance of pain in musculoskeletal diseases and in disease development. In inflamed tissue peripheral nociceptive neurons are rendered hyperexcitable by proinflammatory cytokines, antigen/antibody complexes and other immune mediators. Spinal nociceptive neurons are rendered hyperexcitable with the support of microglial cells, the immune cells of the central nervous system. The so-elicited sensitization of pain pathways has a strong impact on pain processing in the brain. On the other hand, immune processes are regulated by the nervous system. Sensory neurons, by releasing neuropeptides, and efferent neurons of the sympathetic nervous system support immune processes which promote disease development.","PeriodicalId":56108,"journal":{"name":"Neuroforum","volume":"28 1","pages":"77 - 84"},"PeriodicalIF":0.0000,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroforum","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/nf-2022-0001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Abstract Interactions of the immune system and the nociceptive system play an important role in the generation and maintenance of pain in musculoskeletal diseases and in disease development. In inflamed tissue peripheral nociceptive neurons are rendered hyperexcitable by proinflammatory cytokines, antigen/antibody complexes and other immune mediators. Spinal nociceptive neurons are rendered hyperexcitable with the support of microglial cells, the immune cells of the central nervous system. The so-elicited sensitization of pain pathways has a strong impact on pain processing in the brain. On the other hand, immune processes are regulated by the nervous system. Sensory neurons, by releasing neuropeptides, and efferent neurons of the sympathetic nervous system support immune processes which promote disease development.
期刊介绍：
Neuroforum publishes invited review articles from all areas in neuroscience. Readership includes besides basic and medical neuroscientists also journalists, practicing physicians, school teachers and students. Neuroforum reports on all topics in neuroscience – from molecules to the neuronal networks, from synapses to bioethics.
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