Clinical effects of Baduanjin qigong exercise on cancer-related fatigue: A systematic review and meta-analysis

IF 1.9 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE European Journal of Integrative Medicine Pub Date : 2023-10-01 DOI:10.1016/j.eujim.2023.102283

QianQian Liu, LiuYan Zhan, Xue Yan, Yao Li, SiQi Wei

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Abstract

Introduction

A number of randomized controlled trials have investigated the benefits of Baduanjin qigong on cancer-related fatigue (CRF) in cancer survivors. However, the results of these studies were inconclusive and contradictory, due to the limitations of small sample sizes and different measurement scores. We conducted this systematic review and meta-analysis of the evidence available to critically evaluate the efficacy and safety of Baduanjin qigong in improving CRF in cancer patients.

Methods

Eight databases (The Cochrane Library, PubMed, EMBASE, Web of Science, Chinese Biomedical Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP), and WanFang Database)) were systematically reviewed from inception to September 2022 for randomized controlled trials (RCTs). Two reviewers critically and independently assessed the risk of bias using the Cochrane Collaboration criteria and independently extracted relevant data using the designed tables. All statistical analyses were performed using Review Manager 5.3.

Results

Thirteen eligible studies were included in this systematic review, including 1010 patients. Baduanjin qigong as an add-on therapy significantly improved fatigue symptom scores (Standardized mean difference -1.43, 95% CI -2.01 to -0.84, P< 0.0001, RCTs= 9, n = 640). We found that different intervention frequencies, intervention durations, and intervention cycles of Baduanjin qigong exercise were effective in relieving fatigue, and the differences in effectiveness were similar for different types of cancer patients. Two RCTs reported no adverse events associated with Baduanjin qigong.

Conclusion

Baduanjin qigong may reduce CRF in cancer patients and may be used as a traditional and complementary medicine option for the clinical management of CRF. However, large and well-designed randomized controlled trials are still needed to confirm these findings.

Registration

PROSPERO CRD42022369410.

Funding

Lanzhou University, China (grant number 561,120,201) and Natural Science Youth Fund of Gansu Province (grant number 23JRRA1110).

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八段锦气功治疗癌症性疲劳的临床疗效：系统评价和Meta分析

一些随机对照试验研究了八段锦气功对癌症幸存者癌症相关疲劳(CRF)的益处。然而，由于样本量小，测量分数不同，这些研究的结果是不确定和矛盾的。我们对现有证据进行了系统回顾和荟萃分析，以批判性地评估八段金气功改善癌症患者CRF的有效性和安全性。方法系统回顾8个数据库(Cochrane Library、PubMed、EMBASE、Web of Science、中国生物医学数据库(CBM)、中国知网(CNKI)、中国科学期刊数据库(VIP)和万方数据库)，从数据库建立至2022年9月进行随机对照试验(RCTs)。两位审稿人使用Cochrane协作标准独立评估偏倚风险，并使用设计的表格独立提取相关数据。所有统计分析均使用Review Manager 5.3进行。结果本系统评价纳入13项符合条件的研究，包括1010例患者。八段锦气功作为辅助治疗可显著改善疲劳症状评分(标准化平均差为-1.43,95% CI为-2.01 ~ -0.84,P<0.0001, rct = 9, n = 640)。我们发现八段锦气功运动不同的干预频率、干预时间、干预周期均有缓解疲劳的效果，不同类型癌症患者的效果差异相似。两项随机对照试验未报告八段锦气功相关不良事件。结论八段金气功可降低肿瘤患者的恶性循环，可作为临床治疗恶性循环的一种传统辅助药物。然而，仍然需要大规模和精心设计的随机对照试验来证实这些发现。RegistrationPROSPERO CRD42022369410。资助项目:兰州大学(批准号561,120,201)和甘肃省自然科学青年基金(批准号23JRRA1110)。

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来源期刊

European Journal of Integrative Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

4.70

自引率

4.00%

发文量

102

审稿时长

33 days

期刊介绍： The European Journal of Integrative Medicine (EuJIM) considers manuscripts from a wide range of complementary and integrative health care disciplines, with a particular focus on whole systems approaches, public health, self management and traditional medical systems. The journal strives to connect conventional medicine and evidence based complementary medicine. We encourage submissions reporting research with relevance for integrative clinical practice and interprofessional education. EuJIM aims to be of interest to both conventional and integrative audiences, including healthcare practitioners, researchers, health care organisations, educationalists, and all those who seek objective and critical information on integrative medicine. To achieve this aim EuJIM provides an innovative international and interdisciplinary platform linking researchers and clinicians. The journal focuses primarily on original research articles including systematic reviews, randomized controlled trials, other clinical studies, qualitative, observational and epidemiological studies. In addition we welcome short reviews, opinion articles and contributions relating to health services and policy, health economics and psychology.