Diabetic retinal neurodegeneration associated with synaptic proteins and functional defects: A systematic review

Q3 Medicine Endocrine and Metabolic Science Pub Date : 2023-06-30 DOI:10.1016/j.endmts.2023.100127

Siddhita Jadhav , Tos T.J.M. Berendschot , Govindasamy Kumaramanickavel , Eline E.B. De Clerck , Carroll A.B. Webers

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Abstract

Diabetic retinopathy (DR) is the most common ophthalmological complication of diabetes mellitus (DM) and a leading cause of preventable visual impairment. In DM, retinal neurodegenerative changes precede microvascular changes which can be assessed by electrophysiological and advanced imaging techniques. Studies measuring retinal neurodegenerative changes in DM were systematically evaluated in this review. Included studies have assessed retinal neurodegeneration in diabetic rodents by combining clinically used diagnostic techniques and molecular assays. Significant impairment was noticed in electrophysiology data in the diabetic retina as compared to the non-diabetic retina. Also, a significant reduction in synaptic protein levels was noticed in the diabetic retina compared to the non-diabetic retina. Even though retinal neurodegeneration was noticed, no vascular abnormalities were seen in the diabetic retina. However, little is known about molecular mechanisms behind diabetic retinal neurodegeneration (DRN), which explains the need for further investigation to detect DR in the early stages of diabetes.

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糖尿病视网膜神经变性与突触蛋白和功能缺陷相关:系统综述

糖尿病视网膜病变(DR)是糖尿病(DM)最常见的眼科并发症，也是可预防的视力损害的主要原因。在糖尿病中，视网膜神经退行性改变先于微血管改变，这可以通过电生理和先进的成像技术来评估。本综述对测量糖尿病视网膜神经退行性改变的研究进行了系统评价。纳入的研究通过结合临床使用的诊断技术和分子分析来评估糖尿病啮齿动物的视网膜神经变性。与非糖尿病视网膜相比，糖尿病视网膜的电生理数据明显受损。此外，与非糖尿病视网膜相比，糖尿病视网膜中突触蛋白水平显著降低。虽然视网膜神经变性被发现，但在糖尿病视网膜中未见血管异常。然而，关于糖尿病视网膜神经变性(DRN)的分子机制知之甚少，这就解释了在糖尿病早期发现DR的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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