Colistin-Induced Neurotoxicity in a Multidrug-Resistant UTI Patient with Cervical Cancer: A Case Report

Abstract

Introduction: There has been a rise in the reappearance of multidrug-resistant Gram-negative bacteria in recent years. Using polymyxins, such as colistin, as a last-line treatment for these infections has led to renewed interest in the toxic effects of this drug. Case Presentation: In this case report, we present neurological signs and symptoms developed in a patient with a history of cervical cancer four to five hours after receiving colistin for treating a urinary tract infection caused by MDR Pseudomonas aeruginosa with a colony count of > 100,000/L. These signs and symptoms included lower limb hemiparesis, facial paresthesia, decreased deep tendon reflexes, and tinnitus, which were resolved on their own 24 hours after discontinuation of the drug. Antibiotic therapy was continued with pipractate and ciprofloxacin instead. The patient got discharged in stable condition after negative urine culture results.