Effect of a Pseudoallergen-Free Diet in Chronic Spontaneous Urticaria: A Pilot Study

IF 0.3 Q4 ALLERGY Astim Allerji Immunoloji Pub Date : 2022-12-07 DOI:10.21911/aai.693
Esra Saraç, Pelin Kuteyla Can, E. Kocaturk
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Abstract

Objective: The role of dietary factors in the etiopathogenesis of chronic spontaneous urticaria (CSU) has been a matter of discussion and it is widely accepted that most urticaria cases triggered by food are caused by pseudoallergic reactions. In this prospective study, our aim was to investigate the effect of a pseudoallergen-free diet (PAFD) on disease activity, the need for antihistamine use, and the quality of life in patients with CSU. Materials and Methods: The study included adult patients who were on follow up for CSU for a duration of at least 6 months and had symptoms every day or every other day. The patients were given a food diary, which also included assessment of daily disease activity. The daily Urticaria Activity Score (UAS), the Chronic Urticaria Quality of Life Questionnaire score at baseline and at the 4th week, and frequency of antihistamine use were obtained. According to the change in UAS (∆UAS), the patients’ response to PAFD was classified as strong (∆UAS≥8), partial (8>∆UAS≥4), or no response (∆UAS<4). Results: Twenty-three patients, 19 females (82.6%) and 4 males (17.4%), completed the study, the mean age was 43±4.6 years. According to ∆UAS, 6 patients (26.1%) had strong response, 6 (26.1%) had partial response, and 11 (47.8%) were unresponsive to PAFD. The mean ∆UAS value of the patients who responded to PAFD was 8.1 (min:4, max:15). At the end of the study, 9 (39.1%) patients had a significant improvement in their quality of life. There were 6 (26%) patients who both responded to PAFD and had improved quality of life scores. The frequency of antihistamine use decreased in 10 (43.5%) patients. Conclusion: PAFD may help decrease disease activity in CSU. We observed that the frequency of antihistamine use could be reduced and the patient’s quality of life could be improved by adding PFAD to antihistamine therapy.
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无假过敏原饮食对慢性自发性荨麻疹的影响:一项初步研究
目的:饮食因素在慢性自发性荨麻疹(CSU)发病中的作用一直是一个有争议的问题,人们普遍认为大多数由食物引起的荨麻疹是由假过敏反应引起的。在这项前瞻性研究中,我们的目的是调查无假过敏原饮食(PAFD)对CSU患者疾病活动性、抗组胺使用需求和生活质量的影响。材料与方法:本研究纳入随访至少6个月且每天或每隔一天出现症状的成年CSU患者。患者被给予食物日记,其中也包括每日疾病活动的评估。获得每日荨麻疹活动评分(UAS)、慢性荨麻疹生活质量问卷评分(基线和第4周)和抗组胺药使用频率。根据UAS(∆UAS)的变化,将患者对PAFD的反应分为强烈(∆UAS≥8)、部分(8>∆UAS≥4)和无反应(∆UAS<4)。结果:23例患者完成研究,其中女性19例(82.6%),男性4例(17.4%),平均年龄43±4.6岁。根据∆UAS, PAFD强烈反应6例(26.1%),部分反应6例(26.1%),无反应11例(47.8%)。PAFD应答患者的平均∆UAS值为8.1,最小值为4,最大值为15。在研究结束时,9例(39.1%)患者的生活质量有显著改善。有6例(26%)患者对PAFD有反应,并且生活质量评分有所改善。10例(43.5%)患者使用抗组胺药的频率下降。结论:PAFD可降低CSU患者的疾病活动性。我们观察到,在抗组胺治疗中加入PFAD可以减少抗组胺药的使用频率,提高患者的生活质量。
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
10
期刊介绍: Asthma Allergy Immunology has been published three times a year in April, August and December as the official and periodical journal of the Turkish National Society of Allergy and Clinical Immunology since 2003. All articles published in the journal have been available online since 2003. A peer reviewed system is used in evaluation of the manuscripts submitted to Asthma Allergy Immunology. The official language of the journal is English. The aim of the journal is to present advances in the field of allergic diseases and clinical immunology to the readers. In accordance with this goal, manuscripts in the format of original research, review, case report, articles about clinical and practical applications and editorials, short report and letters to the editor about allergic diseases and clinical immunology are published in the journal. The target reader population of the Asthma Allergy Immunology includes specialists and residents of allergy and clinical immunology, pulmonology, internal medicine, pediatrics, dermatology and otolaryngology as well as physicians working in other fields of medicine interested in allergy and immunological diseases.
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